Cerebrovascular response to arousal from NREM and REM sleep
Cerebrovascular response to arousal from NREM and REM sleep
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DOI：
10.1093/sleep/31.3.321
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发表时间：
2008-03-01
期刊：
影响因子：
5.6
通讯作者：
Morgan, Barbara J.
中科院分区：
文献类型：
--
作者：
Bangash, Muhammad Fuad;Xie, Ailiang;Morgan, Barbara J.
研究目的：目的：探讨睡眠唤醒对脑血流速度（CBFV）的影响及其与脑血流动力学和全身血流动力学的关系。（6男5女）应用脉冲多普勒超声检测大脑中动脉血流速度，同时检测睡眠状态在一个实施例中，所述方法包括测量呼吸（EEG、EOG和EMG）、通气（电感体积描记法）、心率（ECG）和动脉压（手指体积描记法）。通过听觉音调诱导唤醒（范围：40-80 dB;持续时间：0.5秒）。结果：在NREM睡眠期间，CBFV在觉醒后下降（-15% +/- 2%;组平均值+/- SEM），在听觉音后9秒达到最低点，随后逐渐恢复到基线。平均动脉压（MAP; +20% +/-1%）和心率（HR;+17%2%）分别在听觉音后5秒和3秒达到峰值。每分钟通气量（V-E）在听觉音后增加（+35% +/-10%）2次呼吸。相反，在REM睡眠期间，CBFV在觉醒后增加（+15% +/-3%），峰值在3秒。MAP（+17% +/- 2%）和HR（+15% +/- 2%）在REM睡眠唤醒期间增加，在音调后5秒和3秒达到峰值。在REM sleep.Conclusions：Arousals从NREM睡眠短暂降低CBFV，而Arousals从REM睡眠短暂增加CBFV，尽管定性和定量的增加MAP，HR，和VE在两个睡眠状态。
Study Objective: To determine the effect of arousal from sleep on cerebral blood flow velocity (CBFV) in relation to associated ventilatory and systemic hemodynamic changes.Participants: Eleven healthy individuals (6 men, 5 women).Measurements: Pulsed Doppler ultrasonography was used to measure CBFV in the middle cerebral artery with simultaneous measurements of sleep state (EEG, EOG, and EMG), ventilation (inductance plethysmography), heart rate (ECG), and arterial pressure (finger plethysmography). Arousals were induced by auditory tones (range: 40-80 dB; duration: 0.5 sec). Cardiovascular responses were examined beat-by-beat for 30 sec before and 30 see after auditory tones.Results: During NREM sleep, CBFV declined following arousals (-15% +/- 2%; group mean +/- SEM) with a nadir at 9 sec after the auditory tone, followed by a gradual return to baseline. Mean arterial pressure (MAP; +20% +/- 1 %) and heart rate (HR; +17% 2%) increased with peaks at 5 and 3 sec after the auditory tone, respectively. Minute ventilation (V-E) was increased (+35% +/- 10%) for 2 breaths after the auditory tone. In contrast, during REM sleep, CBFV increased following arousals (+15% +/- 3%) with a peak at 3 sec. MAP (+17% +/- 2%) and HR (+15% +/- 2%) increased during arousals from REM sleep with peaks at 5 and 3 sec post tone. V E increased (+16% +/- 7%) in a smaller, more sustained manner during arousals from REM sleep.Conclusions: Arousals from NREM sleep transiently reduce CBFV, whereas arousals from REM sleep transiently increase CBFV, despite qualitatively and quantitatively similar increases in MAP, HR, and V E in the two sleep states.