Event-related beamforming: A robust method for presurgical functional mapping using MEG
Event-related beamforming: A robust method for presurgical functional mapping using MEG
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DOI：
10.1016/j.clinph.2007.05.064
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发表时间：
2007-08-01
影响因子：
4.7
通讯作者：
Pang, Elizabeth W.
中科院分区：
文献类型：
--
作者：
Cheyne, Douglas;Bostan, Andreea C.;Pang, Elizabeth W.
目的：我们描述了一种新的空间滤波技术的应用-事件相关波束形成（ERB）-术前功能映射的主要感觉领域使用脑磁图。该方法提供了等效电流偶极子（ECD）建模的替代方案，其潜在地消除了由于铁磁材料（例如，方法：我们比较了12名健康对照受试者和4名金属牙种植体受试者的初级体感（M20）和听觉（M100）诱发反应的ERB和ECD定位结果。数据记录与151通道CTF MEG系统使用标准的术前映射protocols.Results：我们发现了一个高水平的协议之间的两种方法在对照组（整体定位差异为5.9 - 2.2毫米M20和10.4 +/- 5.6毫米M100）。受试者与牙科种植体表现出严重扭曲的诱发反应，不能使用ECD分析，而ERB方法本地化的来源，以预期的解剖location.Conclusions：MEG功能映射可以进行不删除正畸或其他金属种植体使用事件相关的波束形成器分析。空间滤波方法可以克服与MEG扩展其适用性相关的一些限制，特别是在儿科临床环境中。(c)2007年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: We describe the application of a new spatial filtering technique - event-related beamforming (ERB) - for presurgical functional mapping of primary sensory areas using MEG. This method provides an alternative to equivalent current dipole (ECD) modeling that potentially eliminates problems of intracranial magnetic artifacts due to movement of ferromagnetic materials (e.g., orthodontic braces) or eye movements.Methods: We compared localization results for ERB and ECD localization of primary somatosensory (M20) and auditory (M100) evoked responses in 12 healthy control subjects and four subjects with metallic dental implants. Data were recorded with a 151-channel CTF MEG system using standard presurgical mapping protocols.Results: We found a high level of agreement between the two methods in control subjects (overall localization difference was 5.9 2.2 mm for M20 and 10.4 +/- 5.6 mm for M100). Subjects with dental implants showed severely distorted evoked responses that could not be analyzed using ECD, whereas the ERB method localized sources to expected anatomical locations.Conclusions: MEG functional mapping may be carried out without removal of orthodontic or other metallic implants using event-related beamformer analysis.Significance: Spatial filtering methods can overcome some of the limitations associated with MEG expanding its applicability, particularly in pediatric clinical environments. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.