A temperature-responsive copolymer hydrogel in controlled drug delivery
A temperature-responsive copolymer hydrogel in controlled drug delivery
复制标题
控制药物输送中的温度响应型共聚物水凝胶
DOI：
10.1021/ma060486p
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发表时间：
2006-09-19
期刊：
影响因子：
5.5
通讯作者：
Xu, Jian
中科院分区：
文献类型：
--
作者：
Dai, Hongjun;Chen, Qiang;Xu, Jian
研究了聚丙烯酰胺-聚丙烯酸无规共聚物水凝胶的光学跃迁现象。聚丙烯酰胺-共丙烯酸水凝胶在低温时呈不透明的白色，而在快或慢的温度升高时逐渐或急剧透明。同时，水凝胶会随着温度的变化而膨胀或破裂。在温度刺激下，光跃迁和体积膨胀都是可逆的。FT- IR、激光拉曼光谱和1H NMR谱显示了水凝胶中氢键形成和解离的光学和体积跃迁的驱动力。网络的异质性导致这些可逆转变响应温度刺激。详细研究了单体、引发剂和交联剂对水凝胶光学跃迁的影响。在水凝胶的有限域中氢键的形成和解离与网络结构有关。由于P（AAm- co- AAc）水凝胶具有溶胀或塌陷的特性，在药物控释方面具有潜在的应用价值。
A novel optical transition for a hydrogel of polyacrylamide and poly( acrylic acid) random copolymer was observed. The poly( acrylamide- co- acrylic acid) hydrogel is opaque white at low temperature, while it will become transparent gradually or sharply on a fast or slow increase of temperature. Meanwhile, the hydrogel can swell or collapse with changing temperature. Both optical transition and volume swelling are reversible responding to temperature stimuli. The FT- IR, laser Raman, and 1H NMR spectroscopy demonstrated the driving force of optical and volume transition: formation and dissociation of hydrogen bonds in the hydrogel. The heterogeneity of the network results in these reversible transition responding to temperature stimuli. The effects of monomer, initiator, and cross- linker on the optical transition of the hydrogel were studied in detail. The formation and dissociation of hydrogen bonds in the limited domain of the hydrogel is related to the network structure. Because of the property of swelling or collapse, the P( AAm- co- AAc) hydrogel has potential value of application in drug controlled release.