Dietary intake of heat-killed Lactococcus lactis H61 delays age-related hearing loss in C57BL/6J mice.
Dietary intake of heat-killed Lactococcus lactis H61 delays age-related hearing loss in C57BL/6J mice.
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DOI：
10.1038/srep23556
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发表时间：
2016-03-22
影响因子：
4.6
通讯作者：
Kobori M
中科院分区：
文献类型：
--
作者：
Oike H;Aoki-Yoshida A;Kimoto-Nira H;Yamagishi N;Tomita S;Sekiyama Y;Wakagi M;Sakurai M;Ippoushi K;Suzuki C;Kobori M
听力损失（阿勒）是一种常见的与衰老有关的疾病。在这项研究中，我们研究了热灭活乳酸乳球菌亚种的摄入量的影响。Cremoris H61（菌株H61）对C57 BL/6 J小鼠阿勒的影响。听觉脑干反应（ABR）的测量表明，在9个月大的雌性小鼠喂养含有0.05%菌株H61的饮食6个月，保持了显着低于对照组小鼠的ABR阈值。与年龄相关的损失的神经元和毛细胞的耳蜗抑制摄入菌株H61。粪便细菌植物群分析显示，摄入菌株H61增加了乳杆菌目的流行，这与小鼠的听力能力呈正相关。此外，血浆脂肪酸水平与听力呈负相关。总体而言，结果支持摄入热灭活菌株H61 6个月改变了肠道植物群，影响了血浆代谢物水平，包括脂肪酸水平，并延缓了小鼠的阿勒。
Age-related hearing loss (AHL) is a common disorder associated with aging. In this study, we investigated the effect of the intake of heat-killed Lactococcus lactis subsp. cremoris H61 (strain H61) on AHL in C57BL/6J mice. Measurement of the auditory brainstem response (ABR) demonstrated that female mice at 9 months of age fed a diet containing 0.05% strain H61 for 6 months maintained a significantly lower ABR threshold than control mice. The age-related loss of neurons and hair cells in the cochlea was suppressed by the intake of strain H61. Faecal analysis of bacterial flora revealed that the intake of strain H61 increased the prevalence of Lactobacillales, which is positively correlated with hearing ability in mice. Furthermore, plasma fatty acid levels were negatively correlated with hearing ability. Overall, the results supported that the intake of heat-killed strain H61 for 6 months altered the intestinal flora, affected plasma metabolite levels, including fatty acid levels, and retarded AHL in mice.