Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?
Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone?
复制标题
终生累积暴露与对臭氧的急性肺部反应之间是否存在关联？
DOI：
10.1097/jom.0b013e318162f5eb
复制
发表时间：
2008
影响因子：
3.2
通讯作者：
Balmes,JohnR
中科院分区：
文献类型：
--
作者：
Arjomandi,Mehrdad;Tager,IraB;Bastaki,Maria;Chen,Connie;Holland,Nina;Balmes,JohnR
Objective:To investigate the potential effects of lifetime cumulative ozone (O 3) exposure on acute pulmonary responses to O 3.Methods:Fifteen healthy subjects from a larger cohort of young adults were exposed to 200 ppb O 3 for 4 hours followed by bronchoscopy and bronchoalveolar lavage 18 hours later. Lung function, symptom questionnaires, and blood samples were obtained before and after each exposure. Subjects' lifetime cumulative O 3 exposures were estimated from residential histories and air-quality monitoring data.Results:Acute exposure to O 3 caused decrements in forced expiratory volume in 1 second (FEV 1), maximal mid-expiratory flow rate (FEF 25–75), and forced expiratory flow rate at 75% of forced vital capacity (FEF 75), and an increase in plasma clara cell protein (CC16) level. Changes in CC16 and lower respiratory symptoms, but not in lung function, were positively correlated with lifetime cumulative O 3 exposure.Conclusion:Higher lifetime cumulative O 3 exposure was associated with airway injury and respiratory symptom responses, but not with airway inflammatory or lung function responses, to acute O 3 exposure.
