ANTIBODIES TO ACIDIC GLYCOLIPIDS IN GUILLAIN-BARRE-SYNDROME AND CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
ANTIBODIES TO ACIDIC GLYCOLIPIDS IN GUILLAIN-BARRE-SYNDROME AND CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
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DOI：
10.1016/0022-510x(92)90217-9
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发表时间：
1992-01-01
影响因子：
4.4
通讯作者：
COOK, SD
中科院分区：
文献类型：
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作者：
ILYAS, AA;MITHEN, FA;COOK, SD
采用酶联免疫吸附试验和薄层层析免疫染色法，我们检测了53例格林-巴利综合征（GBS）和16例慢性炎症性脱髓鞘性多发性神经病（CIDP）患者中的36例和8例的血清酸性糖脂抗体。 虽然我们也发现了抗酸性糖脂抗体在4 13例其他神经系统疾病; 2 10例多发性硬化症; 8 33例炎症，感染，过敏或自身免疫性疾病和3 32例健康受试者，这些控制的抗体水平远远低于GBS患者。 GBS血清的反应性有几种模式，包括LM 1和HexLM 1、GM 1或GD 1b或两者的抗体、各种其他神经节苷脂、硫酸化糖脂和尚未鉴定的糖脂。 30%的GBS患者血清中有针对两种或两种以上抗原性不同的酸性糖脂抗原的抗体。 11例GBS患者中有9例的抗酸性糖脂抗体水平与临床症状相关。 虽然与对照组相比，GBS（P < 0.001）和CIDP（P < 0.025）患者中酸性糖脂抗体的发生率增加可能是一种附带现象，但抗酸性糖脂抗体可能在一些GBS和CIDP患者的神经损伤中起作用。
Using an enzyme-linked immunosorbent assay and a thin-layer chromatography-immunostaining procedure, we detected serum antibodies against acidic glycolipids in 36 of 53 patients with Guillain-Barre syndrome (GBS) and 8 of 16 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Although we also found anti-acidic glycolipid antibodies in 4 of 13 patients with other neurological diseases; 2 of 10 patients with multiple sclerosis; 8 of 33 patients with inflammatory, infectious, allergic or autoimmune disorders and 3 of 32 healthy subjects, the levels of antibodies in these controls were much lower than in GBS patients. There were several patterns of reactivity of GBS sera including antibodies to LM1 and HexLM1, GM1 or GD1b or both, various other gangliosides, sulfated glycolipids, and as yet unidentified glycolipids. Sera from 30% of GBS patients had antibodies against two or more antigenically distinct acidic glycolipid antigens. Levels of anti-acidic glycolipid antibodies correlated with clinical symptoms in 9 of 11 GBS patients. While the increased incidence of antibodies to acidic glycolipids in patients with GBS (P < 0.001) and CIDP (P < 0.025) compared to controls could be an epiphenomenon, anti-acidic glycolipid antibodies may play a role in nerve injury in some GBS and CIDP patients.