Combined ultrasound and serologic screening for hepatic alveolar echinococcosis in central China
Combined ultrasound and serologic screening for hepatic alveolar echinococcosis in central China
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DOI：
10.4269/ajtmh.2002.66.23
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发表时间：
2002-01-01
影响因子：
3.3
通讯作者：
Craig, PS
中科院分区：
文献类型：
--
作者：
Bartholomot, B;Vuitton, DA;Craig, PS
由多房棘球绦虫引起的泡型棘球蚴病（AE）是一种人畜共患的蠕虫病，可类似恶性肿瘤。20世纪70年代，在中国中部发现了该病的疫源地。本研究的目的是通过超声检查和棘球蚴血清学检测来评估中国甘肃省南部两个地区人群中泡型棘球蚴病的患病率。在回答一份流行病学调查问卷后，来自28个村庄的2482名志愿者接受了超声检查。对所有受试者采于滤纸上的全血、超声图像异常的受试者的血清以及随机选取的无病变或有非典型病变的受试者进行了酶联免疫吸附试验以检测抗体活性的血清学检测。在接受筛查的受试者中，至少有630人（25.3%）观察到一种异常超声图像。在84名受试者（3.4%）中发现了进展性泡型棘球蚴病的典型病变。在80名有进展性泡型棘球蚴病典型病变的患者中，77人（96%）血清学检测呈阳性。超声检查对于在流行地区筛查泡型棘球蚴病是有用的。
Alveolar echinococcosis (AE), caused by Echinococcus multilocularis, is a zoonotic helminthic disease that can mimic malignancy. In the 1970s, foci of the disease were found in central China. The aim of the present study was to estimate the prevalence of AE in humans in 2 districts of south Gansu Province, China, by use of ultrasound and Echinococcus serology. After answering an epidemiological questionnaire, 2,482 volunteers from 28 villages underwent ultrasound. Serology via enzyme-linked immunosorbent assay for antibody activity was performed on whole blood collected on filter paper in all subjects; on serum from subjects with an abnormal ultrasound image; and on randomly chosen subjects that either had no lesions or had atypical lesions. At least one (25.3%) abnormal ultrasound image was observed in 630 of the subjects screened. A typical lesion of progressive AE was found in 84 subjects (3.4%). Serologies were positive in 77 (96%) of 80 of patients who had lesions typical of progressive AE. Ultrasound is useful for screening for AE in endemic regions.