FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase
FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase
复制标题
FERONIA 受体激酶通路通过激活 ABI2 磷酸酶抑制拟南芥中的脱落酸信号传导
DOI：
10.1073/pnas.1212547109
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发表时间：
2012-09-04
影响因子：
11.1
通讯作者：
Luan, Sheng
中科院分区：
文献类型：
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作者：
Yu, Feng;Qian, Lichao;Luan, Sheng
植物的生长和发育是由激素的微妙平衡控制的。生长促进激素和生长抑制激素在作用上经常相互拮抗，但这些事件背后的分子机制仍然很大程度上未知。在这里，我们报告了一个串扰机制，使受体样激酶，FERONIA（FER），生长素促进生长的正调节，抑制脱落酸（阿坝）的响应，通过激活ABI 2，阿坝信号的负调节。FER途径由与鸟嘌呤交换因子GEF 1、GEF 4和GEF 10相互作用的FER激酶组成，这些因子反过来又激活GTdR ROP 11/ARAC 10。拟南芥突变体在FER途径的任何步骤中被破坏，包括fer，gef 1gef 4gef 10或rop 11/arac 10，都显示出ABA过敏反应，暗示FER途径在抑制机制中。在寻找FER通路的靶点时，我们发现ROP 11/ARAC 10蛋白与ABI 2磷酸酶物理相互作用并增强其活性，从而将FER通路与阿坝信号传导的抑制联系起来。
Plant growth and development are controlled by a delicate balance of hormonal cues. Growth-promoting hormones and growth-inhibiting counterparts often antagonize each other in their action, but the molecular mechanisms underlying these events remain largely unknown. Here, we report a cross-talk mechanism that enables a receptor-like kinase, FERONIA (FER), a positive regulator of auxin-promoted growth, to suppress the abscisic acid (ABA) response through activation of ABI2, a negative regulator of ABA signaling. The FER pathway consists of a FER kinase interacting with guanine exchange factors GEF1, GEF4, and GEF10 that, in turn, activate GTPase ROP11/ARAC10. Arabidopsis mutants disrupted in any step of the FER pathway, including fer, gef1gef4gef10, or rop11/arac10, all displayed an ABA-hypersensitive response, implicating the FER pathway in the suppression mechanism. In search of the target for the FER pathway, we found that the ROP11/ARAC10 protein physically interacted with the ABI2 phosphatase and enhanced its activity, thereby linking the FER pathway with the inhibition of ABA signaling.