A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd:YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians
A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd:YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians
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DOI：
10.1097/dss.0000000000002486
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发表时间：
2020-12-01
影响因子：
2.4
通讯作者：
Wanitphakdeedecha, Rungsima
中科院分区：
文献类型：
--
作者：
Ungaksornpairote, Chanida;Manuskiatti, Woraphong;Wanitphakdeedecha, Rungsima
目的比较皮秒激光和调Q激光治疗亚洲人表皮和真皮色素性病变的疗效和安全性。方法选择8例雀斑样痣患者和6例获得性双侧太田样斑疹患者。受试者被随机接受一侧皮秒激光和另一侧调Q激光治疗。结果两种激光系统在4周(p=.034)、12周(p=.039)和24周(p=.027)时临床改善不同，其中85.7%的皮秒和57.2%的调Q激光部位在6个月时有50%的改善。两组副反应发生率和愈合时间无显著差异，但皮秒激光治疗不适感明显低于Q开关激光(p=.05)。结论皮秒激光治疗亚洲人色素性皮损的疗效和耐受性均优于Q开关激光。
BACKGROUND Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated.OBJECTIVE To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians.METHODS Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Subjects was randomly treated with a picosecond laser on one side of the face and a Q-switched laser on the other side. Subjective assessments on pigment clearance, and adverse effect were obtained at Weeks 0, 4, 12, and 24 after the final treatment.RESULTS Clinical improvement differed between the 2 laser systems at Week 4 (p = .034), Week 12 (p = .039), and Week 24 (p = .027), with 85.7% of picosecond and 57.2% of Q-switched laser sites showing >50% improvement at 6 months. There was no significant difference in the incidence of side effect and healing time, but picosecond laser was significantly associated with a lower treatment discomfort (p = .05).CONCLUSION The picosecond laser seems to be more effective and better tolerated than Q-switched laser for the treatment of pigmented lesions in Asians.