Role of Interhemispheric Cortical Interactions in Poststroke Motor Function
Role of Interhemispheric Cortical Interactions in Poststroke Motor Function
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DOI：
10.1177/1545968319862552
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发表时间：
2019-07-22
影响因子：
4.2
通讯作者：
Borich, Michael R.
中科院分区：
文献类型：
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作者：
Palmer, Jacqueline A.;Wheaton, Lewis A.;Borich, Michael R.
背景/目的。我们通过测量经颅磁刺激（TMS）诱发的皮层相干性来研究中风幸存者的大脑半球间的相互作用。我们测试了经颅磁刺激在休息和主动肌肉收缩时对大脑半球间连贯性的影响，并比较了中风和老年人的连贯性。我们评估了大脑半球间的连贯性，麻痹运动功能，和同侧皮质沉默期（iSP）之间的关系。方法.参与者（n = 19）和非（n = 14）慢性中风休息或保持同侧手部肌肉的收缩，同时记录诱发反应TMS的同侧/非优势（i/ndM 1）和对侧/优势（c/dM 1）的初级运动皮层与EEG和在手部肌肉与EMG。我们计算了前和后TMS半球间β相干性（15-30 Hz）在两种条件下的运动区和活动条件下的iSP持续时间。结果在积极的i/ndM 1 TMS，半球间的连贯性增加后立即TMS在对照组，但不是在中风。在卒中组中，活动性cM 1 TMS期间的相干性大于iM 1 TMS。在主动iM 1 TMS的连贯性是中风参与者较少，并与轻瘫手臂运动功能的措施呈负相关。与对照组相比，Paretic iSP更长，并且与手动灵活性的临床测量呈负相关。一致性与不一致性之间没有关系。iSP用于任一组。在休息时，没有观察到组内或组间的连贯性差异。结论. TMS诱发的皮层一致性在手部肌肉激活可以索引半球间的相互作用与中风后运动功能，并可能提供新的见解影响功能恢复的神经机制。
Background/Objective. We investigated interhemispheric interactions in stroke survivors by measuring transcranial magnetic stimulation (TMS)-evoked cortical coherence. We tested the effect of TMS on interhemispheric coherence during rest and active muscle contraction and compared coherence in stroke and older adults. We evaluated the relationships between interhemispheric coherence, paretic motor function, and the ipsilateral cortical silent period (iSP). Methods. Participants with (n = 19) and without (n = 14) chronic stroke either rested or maintained a contraction of the ipsilateral hand muscle during simultaneous recordings of evoked responses to TMS of the ipsilesional/nondominant (i/ndM1) and contralesional/dominant (c/dM1) primary motor cortex with EEG and in the hand muscle with EMG. We calculated pre- and post-TMS interhemispheric beta coherence (15-30 Hz) between motor areas in both conditions and the iSP duration during the active condition. Results. During active i/ndM1 TMS, interhemispheric coherence increased immediately following TMS in controls but not in stroke. Coherence during active cM1 TMS was greater than iM1 TMS in the stroke group. Coherence during active iM1 TMS was less in stroke participants and was negatively associated with measures of paretic arm motor function. Paretic iSP was longer compared with controls and negatively associated with clinical measures of manual dexterity. There was no relationship between coherence and. iSP for either group. No within- or between-group differences in coherence were observed at rest. Conclusions. TMS-evoked cortical coherence during hand muscle activation can index interhemispheric interactions associated with poststroke motor function and potentially offer new insights into neural mechanisms influencing functional recovery.