Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent
Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent
复制标题
DOI：
10.1167/iovs.18-25087
复制
发表时间：
2018-12-01
影响因子：
4.4
通讯作者：
Terasaki, Hiroko
中科院分区：
文献类型：
--
作者：
Miyata, Ryohei;Kondo, Mineo;Terasaki, Hiroko
目的。确定临床特征、预后以及抗血管内皮生长因子 (VEGF) 药物对视网膜中央静脉阻塞 (CRVO) 眼（伴或不伴超常闪烁 ERG 振幅）的影响。方法。研究人员对 48 名 CRVO 患者的 48 只眼睛进行了研究。使用 RETeval 系统记录完全散瞳的眼睛的闪烁 ERG。分析了基波分量的幅度和隐式时间。 “超常闪烁 ERG”被定义为振幅≥未受影响的对侧眼的 117%。 结果。48 只患有 CRVO 的眼睛中有 10 只 (20.8%) 在治疗前表现出超常闪烁 ERG。这 10 只 CRVO 眼与正常对侧眼的隐式时间差异 < 4 毫秒。48 只眼睛的隐式时间延迟与相对振幅之间存在显着相关性。治疗 12 个月后，所有 10 只具有超常闪烁 ERG 的 CRVO 眼均具有非缺血型 CRVO，并且在治疗后 12 个月时，具有超常闪烁 ERG 的 CRVO 眼的视力往往更好（P = 0.058）。表明超常闪烁ERG可能是轻度缺血的征兆，并且这些眼睛具有更好的预后，该结果还表明超常闪烁ERG可能是由CRVO眼中VEGF水平轻度升高后视网膜细胞电活动的变化引起的。
PURPOSE. To determine the clinical characteristics, prognosis, and effect of anti-vascular endothelial growth factor (VEGF) agents on eyes with a central retinal vein occlusion (CRVO) with and without supernormal flicker ERG amplitudes.METHODS. Forty-eight eyes of 48 patients with a CRVO were studied. Flicker ERGs were recorded from fully dilated eyes with the RETeval system. The amplitudes and implicit times of the fundamental component were analyzed. "Supernormal flicker ERGs'' were defined as those whose amplitudes were >= 117% of the unaffected fellow eyes.RESULTS. Ten of the 48 eyes (20.8%) with a CRVO showed supernormal flicker ERGs before the treatment. The difference in the implicit times of these 10 CRVO eyes and those of normal fellow eyes was < 4 millisecond. There was a significant correlation between the implicit time delay and the relative amplitude in the 48 CRVO eyes. All 10 CRVO eyes with supernormal flicker ERGs had the nonischemic type of CRVO and tended to have better visual acuities than did the 28 nonischemic CRVO eyes without supernormal flicker ERGs at 12 months after the treatment (P = 0.058). The CRVO eyes with supernormal flicker ERGs had a significant amplitude reduction after a single injection of an anti-VEGF agent.CONCLUSIONS. These results indicated that the supernormal flicker ERGs can be a sign of a mild degree of ischemia, and these eyes have a better prognosis. The results also suggest that the supernormal flicker ERG may be caused by changes in the electrical activities of retinal cells following a mild increase in the VEGF levels in eyes with CRVO.