CASE-CONTROL STUDIES - MATCHED CONTROLS OR ALL AVAILABLE CONTROLS
CASE-CONTROL STUDIES - MATCHED CONTROLS OR ALL AVAILABLE CONTROLS
复制标题
DOI：
10.1016/0895-4356(94)90111-2
复制
发表时间：
1994-09-01
影响因子：
7.2
通讯作者：
TAJIMA, K
中科院分区：
文献类型：
--
作者：
HAMAJIMA, N;HIROSE, K;TAJIMA, K
为了了解病例对照研究中比值比估计值的变化，将个体匹配抽样的结果与基于大量对照的分析结果进行了比较。研究对象是从1988年至1990年访问爱知癌症中心医院的患者中选择的。病例包括251例男性肺癌患者，年龄40 - 79岁。年龄和就诊年份匹配的对照组分别从非癌症男性门诊患者中独立取样100次和5000次（病例与对照组比例：1：1、1：2、1：3和1：4）。作为不匹配的对照，所有年龄在40 - 79岁的男性非癌症门诊患者（4100例患者）被使用。吸烟习惯被用作暴露变量。正如逻辑预期的那样，基于4100例男性对照的分析得出的估计值高于此处检查的匹配分析，表明当有大量对照可用时，不建议进行匹配采样。
In order to realize the variation in the estimate of the odds ratio from case-control studies, results from individually matched sampling were compared with those from the analysis based on a large number of controls. The subjects were selected from those who visited Aichi Cancer Center Hospital from 1988 to 1990. Cases consisted of 251 male lung cancer patients aged 40-79 years. Age and year of visit matched controls were sampled independently 100 times and 5000 times from non-cancer male outpatients (cases to controls ratio: 1:1, 1:2, 1:3, and 1:4). As unmatched controls, all male noncancer outpatients aged 40-79 years (4100 patients) were used. The smoking habit was adopted as an exposure variable. As logically expected, analysis based on 4100 male controls gave a steadier estimate than the matched analyses examined here, indicating that a matched sampling is not recommended when a large number of controls are available.