Detection of a Meal Using Continuous Glucose Monitoring implications for an artificial β-cell
Detection of a Meal Using Continuous Glucose Monitoring implications for an artificial β-cell
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DOI：
10.2337/dc07-1293
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发表时间：
2008-02-01
期刊：
影响因子：
16.2
通讯作者：
Doyle, Francis J., III
中科院分区：
文献类型：
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作者：
Dassau, Eyal;Bequette, B. Wayne;Doyle, Francis J., III
目的-本研究的目的-，vas介绍一种新的进餐检测算法（MDA），用于作为一个人工的P-细胞的一部分，使用连续血糖监测仪（CGM）。研究设计和方法-我们开发了我们的MDA的数据集上的26个进餐事件的记录，从19名儿童年龄1-6岁谁使用MiniMed CGMS黄金。然后，我们将该算法应用于FreeStyle Navigator动态葡萄糖探头的DirecNet初步研究的CGM记录。在一个研究中心住院期间，早餐胰岛素被扣留1小时，离散的葡萄糖水平在餐后每10分钟获得一次。结果-基于导航仪读数，MDA在从进食开始的平均30分钟检测到进餐，此时平均血清葡萄糖高于基线21 mg/dl（范围2-36 mg/dl），并且在葡萄糖从基线上升40 mg/dl之前检测到>90%的进餐。
OBJECTIVE - The purpose of this Study -,vas to introduce a novel meal detection algorithm (MDA) to be used as part of an artificial P-cell that uses a continuous glucose monitor (CGM).RESEARCH DESIGN AND METHODS - We developed our MDA on a dataset of 26 meal events using records from 19 children aged 1-6 years who Used the MiniMed CGMS Gold. We then applied this algorithm to CGM records from a DirecNet pilot study of the FreeStyle Navigator continuous glucose sensor. During a research center admission, breakfast insulin was withheld for 1 h, and discrete glucose levels were obtained every 10 min after the meal.RESULTS - Based on the Navigator readings, the MDA detected a meal at a mean time of 30 min from the onset of eating, at which time the mean serum glucose was 21 mg/dl above baseline (range 2-36 mg/dl), and >90% of meals were detected before the glucose had risen 40 mg/dl from baseline.CONCLUSIONS - The MDA will enable automated insulin dosing in response to meals, facilitating the development of an artificial pancreas.