Epstein-Barr virus and its association with rheumatoid arthritis and oral lichen planus.
Epstein-Barr virus and its association with rheumatoid arthritis and oral lichen planus.
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DOI：
10.4103/0973-029x.174643
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Malathi N
中科院分区：
文献类型：
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作者：
Adtani P;Malathi N
自身免疫性疾病（autoimmune diseases，AD）的发病机制是多因素参与的。遗传易感性、免疫系统衰竭、激素失衡和环境因素起着重要作用。在许多环境因素中，感染在各种自身免疫性疾病的发病机制中的作用越来越重要;其中，EB病毒（EBV）起着关键作用。文献指出各种AD与EBV相关，即多发性硬化症、自身免疫性甲状腺炎、系统性红斑狼疮、口腔扁平苔藓（OLP）、类风湿性关节炎（RA）、自身免疫性肝炎、干燥综合征和川崎病;其中，最常见的是OLP和RA。鉴于RA、OLP的发生频率，我们的目的是对RA、OLP患者血清中的EBV病毒衣壳抗原（EBV VCA）IgG进行定性分析，并与正常人进行比较。研究实验室的体外实验。从25名诊断为RA和OLP的患者中采集5毫升血液样本。分离血清，用NovaTec EBV VCA IgG ELISA试剂盒检测血清中EBV VCA IgG抗体滴度。卡方检验25例RA受试者中有6例和25例OLP受试者中有4例EBV VCA IgG检测阳性。环境和遗传因素都是自身免疫性疾病的重要组成部分。筛查病毒病因将提高常规治疗的疗效，降低复发的风险。
Pathogenesis of autoimmune diseases (AD) is one of a multifactorial milieu. A genetic predisposition, an immune system failure, hormonal imbalance and environmental factors play important roles. Among the many environmental factors, the role of infection is gaining importance in the pathogenesis of various autoimmune disorders; among them, Epstein–Barr virus (EBV) plays a pivotal role. Literature states an association of various AD with EBV namely multiple sclerosis, autoimmune thyroiditis, systemic lupus erythematous, oral lichen planus (OLP), rheumatoid arthritis (RA), autoimmune hepatitis, Sjögren's syndrome and Kawasaki disease; among these, the most commonly occurring are OLP and RA. Considering the frequency of occurrences, our aim was to perform a qualitative analysis of EBV viral capsid antigen (EBV VCA) IgG in the sera of patients with RA, OLP and establish a comparison with normal. In-vitro experiment in a research laboratory. Five-milliliter blood sample was collected from 25 patients diagnosed with RA and OLP. Serum was separated and EBV VCA IgG antibody titer was detected using NovaTec EBV VCA IgG ELISA kit. Chi-square test. Six out of 25 subjects with RA and 4 out of 25 subjects with OLP tested positive for EBV VCA IgG. Both environmental and genetic factors are important contributory components for autoimmune conditions. Screening for viral etiology would improve the efficacy of conventional treatment and reduce the risk of relapses.