Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome.
Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome.
复制标题
脑血管对唐氏综合症中衰老和阿尔茨海默病的影响。
DOI：
10.1016/j.bbadis.2015.11.007
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Head,Elizabeth
中科院分区：
文献类型：
--
作者：
Wilcock,DonnaM;Schmitt,FrederickA;Head,Elizabeth
唐氏综合症（DS）是智力残疾的常见原因，也与早发阿尔茨海默病（AD）有关。由于21号染色体的额外拷贝，大多数40岁以上患有退行性痴呆的成年人由于淀粉样蛋白前体蛋白的过度表达而出现β -淀粉样斑块。脑血管病理学也可能是在成人退行性椎体滑移患者的大脑中观察到的神经病理学的重要贡献者。本文综述了退行性椎体滑移的心血管功能障碍和脑血管病理特征，这些特征可能是可改变的危险因素，因此是干预的目标。我们将描述脑血管病理，合并症的作用，影像学研究表明血管病理和可能的后果。很明显，我们对退行性椎体滑移患者的衰老和AD的理解将受益于进一步的研究，以确定脑血管功能障碍对认知健康的影响。这篇文章是由Paul Murphy， Roderick a . Corriveau和Donna M. Wilcock编辑的题为“血管对认知障碍和痴呆的贡献”的特刊的一部分。
Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.