Regulation of renal hemodynamics after protein feeding: effects of loop diuretics.
Regulation of renal hemodynamics after protein feeding: effects of loop diuretics.
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蛋白质喂养后肾血流动力学的调节：袢利尿剂的作用。
DOI：
10.1152/ajprenal.1991.261.5.f815
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Smith,BE
中科院分区：
文献类型：
--
作者：
Woods,LL;DeYoung,DR;Smith,BE
这些研究旨在验证高蛋白餐后肾血管舒张和肾小球滤过率（GFR）增加是由肾小管肾小球反馈（TGF）机制介导的假设。在8只慢性仪器清醒的狗中，一餐生牛肉（10 g/kg）导致GFR从66 +/- 5增加到90 +/- 7 ml/min，有效肾血浆流量（ERPF）从191 +/- 25增加到281 +/- 24 ml/min，而血浆α-氨基氮水平从4.0 +/- 0.1上升到7.3 +/- 0.6 mg/dl。在另一天，给狗输注呋塞米以阻断TGF，并不断补充液体和盐的损失。在大多数动物中，呋塞米单独引起GFR增加，尽管平均变化没有达到统计学显著性，ERPF增加了31%。尿钠排泄量从15 +/- 5上升到2,390 +/- 280 μ eq/min，尿流量从1.17 +/- 0.22上升到20.5 +/- 2.4 ml/min。自动调节能力也消失（自动调节指数= 0.87 +/- 0.09，而呋塞米治疗前为0.19 +/- 0.05）。然而，在接受呋塞米的狗中，随后的肉食后GFR和ERPF没有显著变化。在另一天，一些狗给予另一种袢利尿剂，依他尼酸，这不会引起GFR的变化，而其对ERPF，钠排泄和尿量的影响与呋塞米相似。在依他尼酸给药期间，尽管血浆α-氨基N正常增加，但在肉食后GFR或ERPF也没有变化。（250字处删节）
These studies were designed to test the hypothesis that the renal vasodilation and increased glomerular filtration rate (GFR) after a high-protein meal are mediated by the tubuloglomerular feedback (TGF) mechanism. In eight chronically instrumented conscious dogs, a meal of raw beef (10 g/kg) caused GFR to increase from 66 +/- 5 to 90 +/- 7 ml/min and effective renal plasma flow (ERPF) to increase from 191 +/- 25 to 281 +/- 24 ml/min, while plasma alpha-amino N levels rose from 4.0 +/- 0.1 to 7.3 +/- 0.6 mg/dl. On another day the dogs were given an infusion of furosemide to block TGF, and fluid and salt losses were continuously replaced. Furosemide alone caused GFR to increase in most animals, although the average change did not reach statistical significance, and ERPF increased by 31%. Sodium excretion rose from 15 +/- 5 to 2,390 +/- 280 mueq/min, and urine flow rose from 1.17 +/- 0.22 to 20.5 +/- 2.4 ml/min. Autoregulatory capability was also abolished (autoregulatory index = 0.87 +/- 0.09 compared with 0.19 +/- 0.05 before furosemide). However, there was no significant change in GFR and ERPF after a subsequent meat meal in dogs receiving furosemide. On another day, some of the dogs were given another loop diuretic, ethacrynic acid, which caused no change in GFR, whereas its effects on ERPF, sodium excretion, and urine output were similar to those of furosemide. There were also no changes in GFR or ERPF after a meat meal during ethacrynic acid administration, despite normal increases in plasma alpha-amino N.(ABSTRACT TRUNCATED AT 250 WORDS)