Where have all the women gone? Participant gender in epidemiological and non-epidemiological research of schizophrenia
Where have all the women gone? Participant gender in epidemiological and non-epidemiological research of schizophrenia
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DOI：
10.1016/j.schres.2010.03.023
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发表时间：
2010-06-01
影响因子：
4.5
通讯作者：
Gold, James
中科院分区：
文献类型：
--
作者：
Longenecker, Julia;Genderson, Jamie;Gold, James
尽管档案文献表明精神分裂症在男性和女性中同等发生，但最近的流行病学研究报告说，男性精神分裂症的发病率高于女性。此外，有长期证据表明，妇女在非流行病学研究文献中的代表性可能不足。我们的第一个目标是量化2006年发表的非流行病学研究中的性别比例。其次，我们试图在研究中调查哪些因素导致男性人数较多。我们的最终目标是将非流行病学精神分裂症研究中的性别比例与报告的发病率进行比较。在最近的一项发病率荟萃分析中，精神分裂症的男性与女性比例为1.4：1。在精神分裂症患者的非流行病学研究中，平均每名男性与女性的比例为1.94。尽管男性人数超过女性的程度因研究类型和研究领域的不同而有所不同，但在所有调查变量中，研究包括的男性人数都多于女性。要么是男性的发病率比之前报告的要高，要么是女性在研究环境中比在更大的社区中更不明显。重要的是，流行病学研究和非流行病学研究中的性别比例之间的差异是一致的。然而，当男性参与者最多时，存在特定的、可识别的因素，这表明许多研究环境产生了更多的男性。因此，我们对这种疾病及其治疗的大部分了解都是基于对男性进行的不成比例的研究。爱思唯尔出版公司(Elsevier B.V.)
Though archival literature states that schizophrenia occurs equally in males and in females, recent epidemiological studies report higher incidence of schizophrenia in men than in women. Moreover, there is longstanding evidence that women may be under-represented in non-epidemiological research literature. Our first goal was to quantify gender ratios in non-epidemiological research published in 2006. Secondly, we sought to investigate which factors contribute to high numbers of men in research studies. Our final goal was to compare gender ratios in non-epidemiological schizophrenia research to reported incidence rates. In a recent metaanalysis of incidence, there were 1.4 males for each female with schizophrenia. In non-epidemiological studies of the schizophrenia patients, there was an average of 1.94 men for every woman. Although the degree to which men outnumbered women varied according to study type and region of study, research studies included more men than women across all investigated variables. Either the incidence rates are higher for men than has previously been reported or women are less visible in research settings than in the greater community. Importantly, the discrepancy between gender ratios in epidemiological and non-epidemiological research is consistent. However, specific, identifiable factors are present when male participants are greatest, suggesting that many research environments yield a higher number of men. Thus much of our understanding of the illness and its treatment is based on research conducted disproportionately with men. Published by Elsevier B.V.