Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats
Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats
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DOI：
10.1016/j.ejphar.2006.05.017
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发表时间：
2006-08-14
影响因子：
5
通讯作者：
Murakami-Murofushi, Kimiko
中科院分区：
文献类型：
--
作者：
Hotta, Harumi;Kagitani, Fusako;Murakami-Murofushi, Kimiko
研究了一种新型脂质介质环磷脂酸（cPA）对麻醉大鼠呼吸和心血管功能的影响。静脉给药剂量分别为130和390 μ g/kg的3- o -碳-醇乙酯- cpa可使潮气量和呼吸频率呈剂量依赖性增加，导致总通气量增加。在390 μ g/kg剂量下，心率略有下降，而全身动脉压不受影响。迷走神经和颈动脉窦神经的双侧部分旨在消除从外周传入神经到呼吸中枢的主要调节输入，减少了这些反应，但没有消除它们。这些结果表明，cPA通过中枢和外周机制刺激呼吸，作用于脑干的中枢呼吸节律发生器。cPA作为一种呼吸兴奋剂，在治疗呼吸系统疾病时可能具有治疗价值，而不会产生血管加压或心动过速的作用。(c) 2006 Elsevier B.V.版权所有
The effects of a novel lipid mediator, cyclic phosphatidic acid (cPA), on respiratory and cardiovascular functions were examined in anesthetized rats. Intravenous (i.v.) administration of 3-O-carba-olcoyi-cPA at doses of 130 and 390 mu g/kg produced dose-dependent increases in tidal volume and respiratory frequency, resulting in an increase in total ventilation. Heart rate was slightly decreased at a dose of 390 mu g/kg, while systemic arterial pressure was not affected. Bilateral section of vagi and carotid sinus nerves designed to eliminate major regulatory inputs from the peripheral afferents to the respiratory center reduced these responses, but did not abolish them. These results indicate that cPA stimulates respiration, via central and peripheral mechanisms acting on the central respiratory rhythm generator in the brain stem. Administration of cPA may be of therapeutic value as a respiratory stimulant without producing vasopressor or tachycardiac effects, for treatment of respiratory disorders. (c) 2006 Elsevier B.V. All rights reserved.