Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.
Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.
复制标题
DOI：
10.1111/j.1600-065x.2010.00963.x
复制
发表时间：
2010-11
影响因子：
8.7
通讯作者：
Kondo M
中科院分区：
文献类型：
--
作者：
Kondo M
造血干细胞(HSCs)通过一系列的谱系限制步骤不断补充所有类别的血细胞，导致向其他细胞谱系的分化潜能的进行性丧失。本文就造血干细胞成熟过程中最早的分化步骤之一--淋巴系和髓系细胞的分化研究进展作一综述。我们讨论了在鉴定和表征造血干细胞下游祖细胞群体方面的进展，这是理解在分化为某种造血细胞类型的过程中发生的一系列生物学事件的关键。我们还讨论了骨髓微环境在淋系和髓系选择中的重要性。
Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest differentiation steps in HSC maturation, which involves the diversification of the lymphoid and myeloid cell lineages, the two major branches of hematopoietic cells. We discuss progress in the identification and characterization of progenitor populations downstream of HSCs, which has been a key to understanding the sequential biological events that take place along the course of differentiation into a certain hematopoietic cell type. We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice.