Renal Function in Full-Term Newborns Following Neonatal Asphyxia
Renal Function in Full-Term Newborns Following Neonatal Asphyxia
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新生儿窒息后足月新生儿的肾功能
DOI：
10.1177/000992288702600702
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发表时间：
1987
影响因子：
1.6
通讯作者：
M. López
中科院分区：
文献类型：
--
作者：
Fernando Olavarría;Sergio Krause;L. Barranco;Fernando Herrmann;Viviana Paez;S. Mezzano;Nora Leal;M. López
对新生儿窒息的足月儿进行了一项前瞻性研究，以评估肾功能的可能变化。选择出生后1 min Apgar评分≤ 3分的新生儿21例，正常对照组20例。在出生后的前24小时内，少尿12小时或更长时间（小于1 ml/Kg/h）被认为是容量挑战试验和使用利尿剂的指征。对窒息和对照婴儿在出生后24 - 48小时进行肾功能研究（I期），仅对窒息组在48 - 72小时重复进行肾功能研究（II期）。2例患者诊断为内源性急性肾衰竭，其中1例死亡。在10例病例中，肾前性少尿对扩容反应迅速，II期生化指标改善。在9例中，尿量没有改变，所有功能参数与对照组相当。
A prospective study of full-term infants with neonatal asphyxia was performed to evaluate possible alterations in renal function. Twenty-one newborns with an Apgar score ≤ 3 at 1 minute after birth and a control group of 20 normal infants were included. Oliguria of 12 hours or more (less than 1 ml/Kg/h) during the first 24 hours after birth was considered indication for a volume challenge test and use of diuretic. The study of renal function was effected between 24 and 48 hours after birth for asphyxiated and control infants (Period I), and was repeated between 48 and 72 hours (Period II) for the asphyxiated group only. Intrinsic acute renal failure was diagnosed in two patients, one of whom died. In 10 cases, prerenal oliguria responded promptly to volume expansion with improvement of biochemical indices in Period II. In nine cases, urine volume was not altered, and all functional parameters were comparable with those of control.