Bioactive bone cement with a low content of titania particles without postsilanization: Effect of filler content on osteoconductivity, mechanical properties, and handling characteristics
Bioactive bone cement with a low content of titania particles without postsilanization: Effect of filler content on osteoconductivity, mechanical properties, and handling characteristics
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DOI：
10.1002/jbm.b.31731
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发表时间：
2010-11-01
影响因子：
3.4
通讯作者：
Nakamura, T.
中科院分区：
文献类型：
--
作者：
Fukuda, C.;Goto, K.;Nakamura, T.
在本研究中，我们开发了三种类型的聚甲基丙烯酸甲酯 (PMMA) 基复合水泥，其非硅烷化二氧化钛颗粒含量较低（分别为 5、10 和 20 wt% TiO(2)：指定为 T5、T10 和 T20）。将这些骨水泥的骨传导性、机械性能和操作特性与市售 PMMA 骨水泥 (PMMAc) 进行比较。将水泥插入大鼠胫骨并原位固化。 6周和12周后，取出胫骨，使用Stevenel's Blue和Van Gieson's picrofuchsin染色评估骨传导性。反映 T10 和 T20 骨传导性的亲和力指数在 6 周时分别为 33.4 +/- 12.8 和 56.5 +/- 14.1，在 12 周时分别为 67.0 +/- 18.0 和 65.0 +/- 51.7，并且显着高于 PMMAc (p < 0.01)。 T5、T10和T20的压缩强度和弯曲强度超过了PMMAc，但弹性没有显着差异。扫描电镜和能量色散X射线微分析表明，微米级、球形二氧化钛颗粒在T20中分散良好，并暴露在与骨直接接触的骨水泥表面。这些结果表明，T20 是一种有前途的用于假体固定的生物活性骨水泥。 (C) 2010 Wiley periodicals, Inc. J Biomed Mater Res B 部分：Appl Biomater 95B：407-413，2010。
In this study, we developed three types of polymethylmethacrylate (PMMA)-based composite cement with low contents of nonsilanized titania particles (5, 10, and 20 wt% TiO(2), respectively: designated T5, T10, and T20). The osteoconductivity, mechanical properties, and handling characteristics of these cements were compared with those of commercially available PMMA cement (PMMAc). The cement was inserted into rat tibiae and solidified in situ. After 6 and 12 weeks, tibiae were removed for evaluation of osteoconductivity using Stevenel's Blue and Van Gieson's picrofuchsin staining. The affinity indices reflecting the osteoconductivity of T10 and T20 were 33.4 +/- 12.8 and 56.5 +/- 14.1 at 6 weeks, and 67.0 +/- 18.0 and 65.0 +/- 51.7 at 12 weeks, respectively, and were significantly higher than for PMMAc (p < 0.01). The compressive and flexural strengths of T5, T10, and T20 exceeded those of PMMAc, whereas the elasticity did not differ significantly. Scanning electron microscopy and energy-dispersive X-ray microanalysis showed that the micron-sized and spherical titania particles were well dispersed in T20 and were exposed on the surface of the cement that made direct contact with bone. These results show that T20 is a promising bioactive bone cement for use in prosthesis fixation. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 95B: 407-413, 2010.