pH- AND TEMPERATURE-SENSITIVE HYDROGELS BASED ON TRIBLOCK TERPOLYMERS
pH- AND TEMPERATURE-SENSITIVE HYDROGELS BASED ON TRIBLOCK TERPOLYMERS
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基于三嵌段三元聚合物的 pH 和温度敏感水凝胶
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Makromolekulare Chemie
中科院分区：
文献类型：
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作者：
S. Reinicke;J. Schmelz;H. Schmalz;Makromolekulare Chemie
除了少数例外7，这些系统只对一种刺激做出反应，例如温度或pH。在这里，我们报告了双刺激响应性三嵌段共聚物，它对pH和温度都有反应。这些聚合物含有一个可溶于水的聚环氧乙烷(PEO)中间嵌段、一个pH敏感型聚(2-乙烯基吡啶)(P2VP)和一个温度敏感型(LCST)外层嵌段。选择了新型甲基缩水甘油醚和乙基缩水甘油醚的共聚物作为LSCT嵌段。根据三嵌段聚合物在水中的组成和浓度，在加热时可以观察到凝胶-溶胶-凝胶的转变。实验材料。使用SEC-BuLi(Acros，环己烷/正己烷中1.38M)、n-BuLi(Acros，环己烷中2M)、t-BuOK(Aldrich，四氢呋喃中1M)、t-BuP4(FLUKA，正己烷中1M)和t-BuOLi(Aldrich，正己烷中1M)。THF、EO、2VP、DPE的提纯程序可在其他地方找到。8 GME和EGE从CaH_2中蒸馏，先从t-BuOK中缩合，然后从n-BuLi中缩合成安瓶。
With a few exceptions 7 , these systems respond only to one stimulus, e.g. temperature or pH. Here, we report on double-stimuli responsive triblock terpolymers which respond to both, pH and temperature. These polymers contain a water-soluble poly(ethylene oxide) (PEO) middle block, a pH-sensitive poly(2vinylpyridine) (P2VP), and a temperature-sensitive (LCST) outer block. Novel copolymers of methyl and ethyl glycidyl ether were chosen as LSCT block. Depending on composition and concentration of the triblock terpolymers in water, a gel-sol-gel transition upon heating can be observed. Experimental Materials. sec-BuLi (ACROS, 1.38 M in cyclohexane/hexane), n-BuLi (ACROS, 2 M in cyclohexane), t-BuOK (ALDRICH,1 M in THF), t-BuP4 (FLUKA, 1 M in hexane), and t-BuOLi (ALDRICH, 1 M in hexane) were used as received. The purification procedures for THF, EO, 2VP, DPE can be found elsewhere. 8 GME and EGE were distilled from CaH2 and condensed first from t-BuOK and then from n-BuLi into ampoules.