Proton chemical shift imaging: an evaluation of its clinical potential using an in vivo fatty liver model.
Proton chemical shift imaging: an evaluation of its clinical potential using an in vivo fatty liver model.
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质子化学位移成像：使用体内脂肪肝模型评估其临床潜力。
DOI：
10.1148/radiology.154.2.3966134
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发表时间：
1985
期刊：
影响因子：
19.7
通讯作者：
Brady,TJ
中科院分区：
文献类型：
--
作者：
Rosen,BR;Carter,EA;Pykett,IL;Buchbinder,BR;Brady,TJ
通过研究大鼠脂肪肝变化评估了质子化学位移成像 (PCSI) 的潜在实验室和临床实用性，这为组织脂质堆积提供了一个简单的动物模型。体内 PCSI 研究的脂质组信号强度与体外测量获得的肝脏甘油三酯水平之间存在极好的相关性 (R = 0.97)。脂肪肝组织中的体内 T1 弛豫时间测量结果表明存在两个不同的非交换质子群。我们解释了传统磁共振 (MR) 成像研究脂肪肝变化缺乏敏感性的原因，并讨论了我们的发现对其他组织 MR 成像研究的影响。 PCSI 有望在研究各种人类病理状况时提高诊断灵敏度和特异性。
The potential laboratory and clinical utility of proton chemical shift imaging (PCSI) was evaluated by studying fatty liver change in rats, which offered a simple animal model for tissue lipid buildup. There was excellent correlation between lipid group signal intensities from in vivo PCSI studies and liver triglyceride levels obtained from in vitro measurements (R = 0.97). The in vivo T1 relaxation time measurements in fatty liver tissue demonstrated two distinct populations of nonexchanging protons. We explain the reason for the lack of sensitivity in conventional magnetic resonance (MR) imaging studies of fatty liver change and discuss the implications of our findings for MR imaging studies of other tissues. PCSI promises improved diagnostic sensitivity and specificity in studying a wide range of human pathologic conditions.