Phase-Separated Molecular Assembly of a Nanotube Composed of Amphiphilic Polypeptides Having a Helical Hydrophobic Block
Phase-Separated Molecular Assembly of a Nanotube Composed of Amphiphilic Polypeptides Having a Helical Hydrophobic Block
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DOI：
10.1021/acsomega.8b01073
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发表时间：
2018-07-01
期刊：
影响因子：
4.1
通讯作者：
Kimura, Shunsaku
中科院分区：
文献类型：
--
作者：
Itagaki, Toru;Kurauchi, Saki;Kimura, Shunsaku
聚（肌氨酸）-B-（L-or D-Leu-Aib）（6）（SL 12 OMe或SD 12 OMe）和聚（肌氨酸）-B-（L-Leu-Aib）（7）（SL 14 OMe）的两亲性嵌段多肽被报道自组装成纳米管形态。在这里，我们尝试通过粘贴两种不同的纳米管来构建相分离的纳米管。SD 12 OMe纳米管被发现与SL 14 OMe纳米管在50 ℃的热处理下粘附，但粘附产率有限。通过用N-乙基咔唑（SL 12 Ecz）和萘酰亚胺（SD 12 NpiTEG）的芳族基团取代甲酯来官能化两亲性多肽，但它们失去形成均匀纳米管的能力。混合在形成纳米管的两亲性多肽中的官能化两亲性多肽的一部分，SL 12 OMe和SL 12 Ecz（9：1）的混合物以及SD 12 OMe和SD 12 NpiTEG（9：1）的混合物，允许纳米管形成。这两种纳米管通过在15 ℃下的热处理部分地粘在一起，以保持两种芳香族基团沿着纳米管的分离状态，从而形成相分离的纳米管。
Amphiphilic block polypeptides of poly( sarcosine)-b-(L-or D-Leu-Aib)(6) (SL12OMe or SD12OMe) and poly(sarcosine)-b-(L-Leu-Aib)(7) (SL14OMe) were reported to self-assemble into a nanotube morphology. Herein, we tried to construct a phase-separated nanotube by sticking two different kinds of nanotubes. SD12OMe nanotubes were found to stick to SL14OMe nanotubes with a heat treatment at 50 degrees C, but the sticking yield was limited. The amphiphilic polypeptides were functionalized by replacement of methyl ester with aromatic groups of N-ethylcarbazole (SL12Ecz) and naphthalimide (SD12NpiTEG), but they lost the ability to form homogeneous nanotubes. A fraction of the functionalized amphiphilic polypeptides mixing in the nanotube-forming amphiphilic polypeptides, a mixture of SL12OMe and SL12Ecz (9:1) as well as a mixture of SD12OMe and SD12NpiTEG (9:1), allowed nanotube formation. These two kinds of nanotubes partly stuck together with a heat treatment at 15 degrees C to maintain a segregated state of two kinds of aromatic groups along the nanotube, resulting in the formation of a phase-separated nanotube.