The transport of nanosized gene carriers unraveled by live-cell imaging
The transport of nanosized gene carriers unraveled by live-cell imaging
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DOI：
10.1002/anie.200503021
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Zumbusch, A
中科院分区：
文献类型：
--
作者：
Bausinger, R;von Gersdorff, K;Zumbusch, A
跟踪运输：阳离子聚乙烯亚胺纳米颗粒作为非病毒载体，将 DNA 递送至细胞核。荧光活细胞成像突出显示了转染后续阶段中这些复合物与细胞骨架之间的相互作用（见图）。对基础传输过程的分析为进一步的化学合成方法提供了新的动力。
Tracking transport: Cationic polyethylenimine nanoparticles serve as nonviral vectors and deliver DNA to the nucleus of cells. Fluorescence live‐cell imaging highlights the interactions between these polyplexes and the cytoskeleton during the subsequent stages of transfection (see picture). The analysis of the underlying transport processes gives new impulse to further chemical‐synthesis approaches.