Parametric imaging of ligand-receptor binding in PET using a simplified reference region model
Parametric imaging of ligand-receptor binding in PET using a simplified reference region model
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DOI：
10.1006/nimg.1997.0303
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发表时间：
1997-11-01
期刊：
影响因子：
5.7
通讯作者：
Cunningham, VJ
中科院分区：
文献类型：
--
作者：
Gunn, RN;Lammertsma, AA;Cunningham, VJ
提出了一种利用PET生成放射性配体-受体结合的参数图像的方法。该方法是基于一个简化的参考区域房室模型，它不需要动脉血液采样，并给出参数图像的放射性配体的结合潜力和其相对于参考区域的局部递送速率。该技术提出的模型中的参数估计采用了一组基函数，使纳入参数的界限。利用模拟数据和真实的数据，将这种基函数法（BFM）与传统的非线性最小二乘参数估计（NLM）进行比较。BFM被证明是更稳定的比NLM在体素水平，是计算速度快得多。该技术在三种放射性示踪剂中的应用：[C-11]雷氯必利（D2受体的标记物），人体研究中的[C-11]SCH 23390（D1受体的标记物）和大鼠中的[C-11]CFT（多巴胺转运蛋白的标记物）。隐含在模型中的假设和使用BFM的实现进行了讨论。(C)北京：科学出版社.
A method is presented for the generation of parametric images of radioligand-receptor binding using PET. The method is based on a simplified reference region compartmental model, which requires no arterial blood sampling, and gives parametric images of both the binding potential of the radioligand and its local rate of delivery relative to the reference region. The technique presented for the estimation of parameters in the model employs a set of basis functions which enables the incorporation of parameter bounds. This basis function method (BFM) is compared with conventional nonlinear least squares estimation of parameters (NLM), using both simulated and real data. BFM is shown to be more stable than NLM at the voxel level and is computationally much faster. Application of the technique is illustrated for three radiotracers: [C-11]raclopride (a marker of the D2 receptor), [C-11]SCH 23390 (a marker of the D1 receptor) in human studies, and [C-11]CFT (a marker of the dopamine transporter) in rats. The assumptions implicit in the model and its implementation using BFM are discussed. (C) 1997 Academic Press.