Influence of alcohol consumption on immunological status:: a review
Influence of alcohol consumption on immunological status:: a review
复制标题
DOI：
10.1038/sj.ejcn.1601486
复制
发表时间：
2002-08-01
影响因子：
4.7
通讯作者：
Marcos, A
中科院分区：
文献类型：
--
作者：
Díaz, LE;Montero, A;Marcos, A
本综述的目的是介绍和讨论不同水平的酒精消费对免疫系统的影响。为了确定对免疫活性细胞的活性、数量、分布、平衡、相互作用和反应的影响，不仅要考虑酒精饮料的消耗量，还要考虑酒精饮料的类型。酒精暴露与酒精相关疾病风险之间的关联是多因素的。事实上，年龄、性别、吸烟习惯、饮食摄入和运动等因素都涉及。对宿主细胞和体液免疫反应的评估表明，适度饮酒可能会产生一些益处。此外，那些含有抗氧化剂的酒精饮料，如红酒，可以保护免疫细胞免受损害。根据所查阅的文献，妇女和男子每天分别消费10-12克和20-24克酒精被认为是适度摄入量;在界定适度时，饮料类型已被确定为不重要。特别关注的是U形或J形曲线，这也表明轻度至中度饮酒会产生保护作用。这种相反的关系表明，轻度和中度消费者的风险降低，不仅对酗酒者，而且对非消费者的风险更高。
The aim of this review is to present and discuss the effect of different levels of alcohol consumption on the immune system. Not only the amount consumed but also the type of alcoholic beverage have to be taken into account in order to determine the consequences on activity, number, distribution, balance, interaction and response of immunocompetent cells. The association between alcohol exposure and the risk of developing an alcohol-related disease is multifactorial. In fact, age, gender, smoking habits, dietary intake and exercise are involved among other factors. The evaluation of the host cellular and humoral immune responses has shown that alcohol may induce some benefits when consumption is moderate. Moreover, those alcoholic beverages that contain antioxidants, such as red wine, could be protectors against immune cell damage. According to the literature consulted, the daily consumption of 10-12 g and 20-24 g of alcohol for women and men, respectively, is considered to be a moderate intake; the type of beverage has been established not to be important when defining moderation. Particular attention is often focused on the U- or J-shaped curve which also suggests that light to moderate drinking produces a protective effect. Such an inverse relationship indicates a reduction of risk for both light and moderate consumers and a higher risk not only for hard drinkers, but also for non-consumers.