Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides
Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides
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DOI：
10.1021/ol0505555
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发表时间：
2005-05-12
期刊：
影响因子：
5.2
通讯作者：
Li, CZ
中科院分区：
文献类型：
--
作者：
Hu, TS;Li, CZ
首次研究了铜催化碘代酰胺的分子内乙烯化反应。以CuI为催化剂，N，N-二甲基乙二胺为配体，碘代酰胺在二氧六环中发生环化反应，生成5 - 7元内酰胺，产率适中。
Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With Cul as the catalyst and N,N-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.