Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.
Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.
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DOI：
10.1093/oxfordjournals.molbev.a040752
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发表时间：
1992-07
影响因子：
10.7
通讯作者：
K. Tamura
中科院分区：
文献类型：
--
作者：
K. Tamura
通过将Kimura（1980）的双参数方法扩展到存在G+ C含量偏差的情况，开发了一种简单的数学方法来估计两个DNA序列之间每个位点的核苷酸替换数。这种方法将是有用的，当有很强的转换颠换和G+ C含量的偏见，在果蝇线粒体DNA的情况下。
A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.