Fluorinated analogs of malachite green: Synthesis and toxicity
Fluorinated analogs of malachite green: Synthesis and toxicity
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DOI：
10.3390/molecules13040986
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发表时间：
2008-04-01
期刊：
影响因子：
4.6
通讯作者：
Parvin, Bahram
中科院分区：
文献类型：
--
作者：
Kraus, George A.;Jeon, Insik;Parvin, Bahram
合成了一系列含氟孔雀石绿类似物，并检测了它们对酿酒酵母菌和人卵巢上皮细胞系的毒性。发现这两个物种的毒性谱是不同的。两种类似物，一种是2,4-二氟取代，另一种是2-氟取代，似乎是最有希望的类似物，因为它们对人体细胞的毒性最低。
A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.