Improvements in motor behavioral tests during deep brain stimulation of the subthalamic nucleus in rats with different degrees of unilateral parkinsonism
Improvements in motor behavioral tests during deep brain stimulation of the subthalamic nucleus in rats with different degrees of unilateral parkinsonism
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DOI：
10.1016/j.brainres.2006.08.073
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发表时间：
2006-11-20
期刊：
影响因子：
2.9
通讯作者：
Namba, Hiroki
中科院分区：
文献类型：
--
作者：
Fang, Xin;Sugiyama, Kenji;Namba, Hiroki
脑深部电刺激（DBS）改善帕金森病（PD）患者的运动表现。为了评估丘脑下核(STN)-DBS对运动行为受损的影响，我们研究了在纹状体注射6-羟多巴胺导致黑质纹状体多巴胺系统轻度和重度损伤的大鼠，在对STN进行单侧刺激后，运动表现的改善。在DBS前后对大鼠进行训练和运动行为测试，包括旋转行为测试、步进测试和旋转棒测试。我们证明，电流强度为200 mu a的刺激，在这两组中停止了大部分d -安非他明引起的旋转行为，改善了轻度组和重度组的运动障碍，并且轻度组的改善明显优于重度组。需要更多的实验和临床研究来评估STN-DBS对不同阶段PD的疗效。(c) 2006 Elsevier B.V.版权所有
Deep brain stimulation (DBS) improves motor performance in Parkinson's disease (PD) patients. To evaluate the effects of subthalamic nucleus (STN)-DBS on impaired motor behavior, we studied improvements in motor performance after delivery of unilateral stimulation to the STN in rats with mild and severe lesions of the nigrostriatal dopamine system caused by injecting 6-hydroxydopamine into the striatum. The rats were trained and performed motor behavioral tests including rotational behavior test, stepping test, and rotarod test before and after receiving DBS. We demonstrated that stimulation at a current strength of 200 mu A, which stopped most of the D-amphetamine-induced rotational behaviors in these two groups, improved movement impairments in both the mild and severe groups and that the improvements in the mild group were significantly better than those in the severe group. More experimental and clinical studies are needed to evaluate the efficiency of STN-DBS for different stages of PD. (c) 2006 Elsevier B.V. All rights reserved.