The neuronal mechanisms underlying improvement of impulsivity in ADHD by theta/beta neurofeedback.
The neuronal mechanisms underlying improvement of impulsivity in ADHD by theta/beta neurofeedback.
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DOI：
10.1038/srep31178
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发表时间：
2016-08-12
影响因子：
4.6
通讯作者：
Beste C
中科院分区：
文献类型：
--
作者：
Bluschke A;Broschwitz F;Kohl S;Roessner V;Beste C
神经反馈越来越被认为是治疗注意缺陷多动障碍（ADHD）核心症状的一种干预措施。尽管已经进行了大量的研究来评估其有效性，但与ADHD的核心症状相关的神经元机制受到神经反馈的调节仍然很难理解。19名ADHD儿童接受了8周的theta/beta神经反馈，17名等待名单对照儿童在前-后设计中执行了Go/Nogo任务。我们使用神经生理学的措施相结合的高密度脑电图记录与源定位分析，使用sLORETA。与等待列表ADHD对照组相比，神经反馈治疗后测量的冲动行为减少。神经反馈的效果是非常具体的情况下，需要抑制控制的反应。神经生理数据表明，知觉门控、注意选择和资源分配过程不受神经反馈的影响。相反，神经反馈效应似乎是基于内侧额叶皮层的反应抑制过程的调制。这项研究表明，冲动性背后的特定神经机制是由ADHD中的θ/β神经反馈调节的。所应用的神经反馈协议可能特别适合于解决抑制控制。该研究验证了假设的功能神经解剖目标区域的神经生理水平上建立的神经反馈协议。
Neurofeedback is increasingly recognized as an intervention to treat core symptoms of attention deficit hyperactivity disorder (ADHD). Despite the large number of studies having been carried out to evaluate its effectiveness, it is widely elusive what neuronal mechanisms related to the core symptoms of ADHD are modulated by neurofeedback. 19 children with ADHD undergoing 8 weeks of theta/beta neurofeedback and 17 waiting list controls performed a Go/Nogo task in a pre-post design. We used neurophysiological measures combining high-density EEG recording with source localization analyses using sLORETA. Compared to the waiting list ADHD control group, impulsive behaviour measured was reduced after neurofeedback treatment. The effects of neurofeedback were very specific for situations requiring inhibitory control over responses. The neurophysiological data shows that processes of perceptual gating, attentional selection and resource allocation processes were not affected by neurofeedback. Rather, neurofeedback effects seem to be based on the modulation of response inhibition processes in medial frontal cortices. The study shows that specific neuronal mechanisms underlying impulsivity are modulated by theta/beta neurofeedback in ADHD. The applied neurofeedback protocol could be particularly suitable to address inhibitory control. The study validates assumed functional neuroanatomical target regions of an established neurofeedback protocol on a neurophysiological level.