Y genetic data support the Neolithic demic diffusion model
Y genetic data support the Neolithic demic diffusion model
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DOI：
10.1073/pnas.162158799
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发表时间：
2002-08-20
影响因子：
11.1
通讯作者：
Beaumont, MA
中科院分区：
文献类型：
--
作者：
Chikhi, L;Nichols, RA;Beaumont, MA
关于欧洲人基因库的起源，人们仍然没有达成普遍的共识，尽管欧洲比其他任何大陆都被研究得更彻底。特别是，关于欧洲旧石器时代狩猎采集者和近东新石器时代移民农民的相对贡献一直存在争议，他们将农业带到了欧洲。在这里，我们应用我们已经开发的统计框架，以获得直接估计的贡献，这两个群体在他们见面的时候。我们分析了一个大的数据集的22个二进制标记的非重组区域的Y染色体（NRY），通过使用系谱似然为基础的方法。结果显示，一个显着更大的遗传贡献，新石器时代的农民比以前的间接方法的基础上，通过使用事后标准选择的单倍型的分布。我们发现，在近东和西欧之间的整个范围内，混合物显着减少。我们还认为，当地的狩猎采集者在最初的定居点贡献不到30%。这一发现使我们拒绝农业的主要文化传播。相反，我们认为，由Ammerman和Cavalli-Sforza [Ammerman，A. J. & Cavalli-Sforza，L. L.（1984）新石器时代的过渡和欧洲人口的遗传学（普林斯顿大学出版社，普林斯顿）]抓住了欧洲史前史这一戏剧性事件的主要特征。
There still is no general agreement on the origins of the European gene pool, even though Europe has been more thoroughly investigated than any other continent. In particular, there is continuing controversy about the relative contributions of European Palaeolithic hunter-gatherers and of migrant Near Eastern Neolithic farmers, who brought agriculture to Europe. Here, we apply a statistical framework that we have developed to obtain direct estimates of the contribution of these two groups at the time they met. We analyze a large dataset of 22 binary markers from the non-recombining region of the Y chromosome (NRY), by using a genealogical likelihood-based approach. The results reveal a significantly larger genetic contribution from Neolithic farmers than did previous indirect approaches based on the distribution of haplotypes selected by using post hoc criteria. We detect a significant decrease in admixture across the entire range between the Near East and Western Europe. We also argue that local hunter-gatherers contributed less than 30% in the original settlements. This finding leads us to reject a predominantly cultural transmission of agriculture. Instead, we argue that the demic diffusion model introduced by Ammerman and Cavalli-Sforza [Ammerman, A. J. & Cavalli-Sforza, L. L. (1984) The Neolithic Transition and the Genetics of Populations in Europe (Princeton Univ. Press, Princeton)] captures the major features of this dramatic episode in European prehistory.