Complementary and overlapping selectivity of the two-peptide bacteriocins plantaricin EF and JK
Complementary and overlapping selectivity of the two-peptide bacteriocins plantaricin EF and JK
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DOI：
10.1128/jb.181.16.4848-4852.1999
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发表时间：
1999-08-01
影响因子：
3.2
通讯作者：
Driessen, AJM
中科院分区：
文献类型：
--
作者：
Moll, GN;van den Akker, E;Driessen, AJM
植物乳杆菌素EF和JK是由植物乳杆菌C11产生的两肽类细菌素。plantarum965细胞。两种植物毒素都在靶细胞的膜中形成孔，并耗散跨膜电位（Δ psi）和pH梯度（Δ pH）。植物菌素EF孔有效地传导小的一价阳离子，但阴离子的电导率低或不存在。Plantaricin JK孔对特定阴离子显示高电导率，但对阳离子显示低电导率。plantarum C11产生具有互补离子选择性的细菌素，从而确保有效杀死目标细菌。
Plantaricin EF and JK are both two-peptide bacteriocins produced by Lactobacillus plantarum C11, The mechanism of plantaricin EF and JK action was studied on L. plantarum 965 cells. Both plantaricins form pores in the membranes of target cells and dissipate the transmembrane electrical potential (Delta psi) and pH gradient (Delta pH). The plantaricin EF pores efficiently conduct small monovalent cations, but conductivity for anions is low or absent. Plantaricin JK pores show high conductivity for specific anions but low conductivity for cations, These data indicate that L. plantarum C11 produces bacteriocins with complementary ion selectivib, thereby ensuring efficient killing of target bacteria.