Biocompatibility and nanostructured materials: applications in nanomedicine
Biocompatibility and nanostructured materials: applications in nanomedicine
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DOI：
10.1080/21691401.2016.1178134
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发表时间：
2017-06-01
影响因子：
5.8
通讯作者：
Ghanbari, Hossein
中科院分区：
文献类型：
--
作者：
Adabi, Mahdi;Naghibzadeh, Majid;Ghanbari, Hossein
人们对纳米材料在生物医学科学中的应用产生了巨大的兴趣，包括诊断，药物输送和人体器官的发育。这些纳米材料的数量已经在人体或临床前试验中进行了研究。人们越来越关注纳米材料对人类健康的潜在毒性和不良影响，包括缺乏评估这些材料毒理学的标准方法。我们的研究表明，裸露的和小的纳米粒子具有更高的毒性比改性和散装材料，分别。此外，球形纳米颗粒由于机体的免疫应答而具有比棒状纳米颗粒更小的毒性。
There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body.