Evidence for the long-term stability of HIV transmission-associated sexual behavior after HIV diagnosis.
Evidence for the long-term stability of HIV transmission-associated sexual behavior after HIV diagnosis.
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DOI：
10.1097/olq.0b013e3182753327
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发表时间：
2013-01
影响因子：
3.1
通讯作者：
Golden MR
中科院分区：
文献类型：
--
作者：
Dombrowski JC;Harrington RD;Golden MR
大多数被诊断患有艾滋病毒的人都会改变性行为，以降低艾滋病毒传播的风险，但这种行为改变的持久性尚不清楚。我们对 2005 年至 2009 年间在华盛顿州西雅图一家大型公立医院 HIV 诊所预约的随机选择的患者进行了年度匿名横断面调查。我们使用逻辑回归来评估自 HIV 诊断以来的时间与自我报告与 HIV 阴性或未知的伴侣（不一致的 UAVI）进行无保护肛交或阴道性交 (UAVI) 之间的关联，并使用分位数回归来评估自 HIV 诊断以来的时间与肛交或阴道性交次数之间的关联合作伙伴。我们分析了 5 年来收集的 845 份调查。 MSM 被诊断出感染 HIV 的时间平均为 12 (SD 7) 年，非 MSM 平均为 11 (SD 6) 年。在 597 名 MSM 中，HIV 诊断后时间越长，报告不一致 UAVI 的年龄调整几率越低 [(OR 0.96 (95% CI: 0.92 – 0.99)] 和年龄调整性伴侣数量较低（β 系数 -0.03，p=0.007）。在 248 名女性和异性恋男性中，HIV 诊断后时间与报告不一致 UAVI 的年龄调整几率不显着相关。不一致的 UAVI [OR 0.99 (95% CI: 0.93 – 1.04)] 或性伴侣数量（β 系数 -0.01，p=0.48）。这些结果表明，在 HIV 诊断后第一年，与 HIV 传播相关的行为相对稳定。我们的研究结果表明，其他研究报告的 HIV 诊断后第一年的行为变化是持久的。
Most persons diagnosed with HIV alter their sexual behavior in a way that reduces the risk of HIV transmission, but the durability of such behavior change is unknown. We conducted annual anonymous cross-sectional surveys in randomly selected patients with appointments at a large, public hospital HIV Clinic in Seattle, Washington from 2005 to 2009. We used logistic regression to assess the association between time since HIV diagnosis and self-report of unprotected anal or vaginal intercourse (UAVI) with partners of negative or unknown HIV status (nonconcordant UAVI), and quantile regression to evaluate the association between time since HIV diagnosis and number of anal or vaginal sex partners. We analyzed 845 surveys collected over 5 years. MSM had been diagnosed with HIV a mean of 12 (SD 7) years and non-MSM a mean of 11 (SD 6) years. Among 597 MSM, longer time since HIV diagnosis was associated with lower age-adjusted odds of reporting nonconcordant UAVI [(OR 0.96 (95% CI: 0.92 – 0.99)] and a lower age-adjusted number of sex partners (β coefficient −0.03, p=0.007). Among 248 women and heterosexual men, time since HIV diagnosis was not significantly associated with age-adjusted odds of nonconcordant UAVI [OR 0.99 (95% CI: 0.93 – 1.04)] or number of sex partners (β coefficient −0.01, p=0.48). These results indicate that HIV transmission-associated behavior is relatively stable following the first year after HIV diagnosis. Our findings suggest that behavior change in the first year after HIV diagnosis, reported in other studies, is durable.