Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis.
Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis.
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DOI：
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发表时间：
2007
影响因子：
8.6
通讯作者：
T. Umemura;M. Ota;K. Yoshizawa;Y. Katsuyama;Tetsuya Ichijo;E. Tanaka;S. Kawa;K. Kiyosawa
中科院分区：
文献类型：
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作者：
T. Umemura;M. Ota;K. Yoshizawa;Y. Katsuyama;Tetsuya Ichijo;E. Tanaka;S. Kawa;K. Kiyosawa
自身免疫性肝炎（AIH）是一种器官特异性自身免疫性疾病，其特征是肝脏的慢性炎症。虽然HLA-DRB 1 *0405等位基因与日本人的1型AIH相关，但AIH的确切遗传病因学仍未确定。最近，Fc γ受体（Fc γ R）和Fc受体样基因3（FCRL 3）的多态性与多种自身免疫性疾病有关，并可能至少部分负责AIH的易感性。在这项研究中，我们使用TaqMan检测法对87名日本1型AIH患者和97名种族匹配的对照进行了FcgammaRIIA、FcgammaRIIB和4种FCRL 3多态性的基因分型。尽管我们能够检测到FCRL 3 - 110 A/A基因型AIH患者血清IgG浓度显著降低，但我们观察到患者和对照组之间的基因型分布没有差异，这意味着日本患者对1型AIH的易感性不受Fc γ RIIA、Fc γ RIIB或FCRL 3多态性的影响。
Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined. Recently, polymorphisms of Fcgamma receptors (FcgammaR) and Fc receptor-like gene 3 (FCRL3) were linked to a variety of autoimmune diseases, and may be at least partially responsible for susceptibility to AIH. In this study, we genotyped FcgammaRIIA, FcgammaRIIB, and four FCRL3 polymorphisms in 87 Japanese patients with type 1 AIH and 97 ethnically matched controls using the TaqMan assay. Although we were able to detect significantly lower serum IgG concentrations in AIH patients specifically with the FCRL3-110A/A genotype, we observed no difference in the distribution of the genotypes between patients and controls, implying that susceptibility to type 1 AIH in Japanese patients is not influenced by FcgammaRIIA, FcgammaRIIB, or FCRL3 polymorphisms.