The function of miRNA in cardiac hypertrophy.
The function of miRNA in cardiac hypertrophy.
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miRNA在心脏肥大中的作用
DOI：
10.1007/s00018-012-1126-y
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发表时间：
2012-11
影响因子：
8
通讯作者：
Yang, Xiao
中科院分区：
文献类型：
--
作者：
Wang, Jian;Yang, Xiao
心肌肥大是心肌对应激或损伤的适应性扩张。心肌细胞和非心肌细胞对各种信号通路的细胞反应应受到严格和微妙的调节，以维持心脏稳态并防止病理性心脏肥大。microRNA（miRNAs）是内源性的单链短非编码RNA，通过促进靶mRNA的降解或抑制靶mRNA的翻译来调节基因表达。最近的研究揭示了与人类和小鼠心脏病模型中的病理性心脏肥大和心力衰竭相关的miRNA的表达特征。越来越多的证据表明，特异性miRNAs的异常调节可改变心肌细胞和非心肌细胞对病理性血流动力学超负荷时特异性信号的反应，导致心肌肥大和心力衰竭。本文综述了心肌细胞miRNAs的细胞自主性功能的不同调控途径以及非心肌细胞miRNAs在心肌肥厚中的作用。一些miRNAs在心脏疾病中的治疗作用也进行了讨论。
Cardiac hypertrophy is an adaptive enlargement of the myocardium in response to altered stress or injury. The cellular responses of cardiomyocytes and non-cardiomyocytes to various signaling pathways should be tightly and delicately regulated to maintain cardiac homeostasis and prevent pathological cardiac hypertrophy. MicroRNAs (miRNAs) are endogenous, single-stranded, short non-coding RNAs that act as regulators of gene expression by promoting the degradation or inhibiting the translation of target mRNAs. Recent studies have revealed expression signatures of miRNAs associated with pathological cardiac hypertrophy and heart failure in humans and mouse models of heart diseases. Increasing evidence indicates that dysregulation of specific miRNAs could alter the cellular responses of cardiomyocytes and non-cardiomyocytes to specific signaling upon the pathological hemodynamic overload, leading to cardiac hypertrophy and heart failure. This review summarizes the cell-autonomous functions of cardiomyocyte miRNAs regulated by different pathways and the roles of non-cardiomyocyte miRNAs in cardiac hypertrophy. The therapeutic effects of a number of miRNAs in heart diseases are also discussed.
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