A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
复制标题
用于药物输送和癌症成像的肿瘤选择性级联可激活自滞系统
DOI：
10.1038/s41467-019-12848-5
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发表时间：
2019-10-24
影响因子：
16.6
通讯作者：
Zhao, Yuliang
中科院分区：
文献类型：
--
作者：
An, Hong-Wei;Li, Li-Li;Zhao, Yuliang
在细胞系统内实现药物的激活可能会提供靶向治疗。在这里，我们构建了一个肿瘤选择性级联可激活自滞式系统(TCASS)，并结合了成像探针和治疗方法。我们在不同的小鼠模型中显示，TCASS系统在实体瘤中积累。这些分子通过识别诱导的自组装效应，在肿瘤区域显示出增强的聚集。分子在肿瘤组织中的穿透分析表明，与典型的软或硬纳米材料相比，体内自组装增强了穿透能力。重要的是，体内自组装的分子表现出与小分子类似的清除途径，小分子从网状内皮系统的器官(肝脏和肾脏)排泄，而从肿瘤组织中的清除相对缓慢。最后，该系统与近红外探头相结合，对分离的完整患者膀胱癌的检测显示出高的特异性和敏感性。
Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.