Effect of vascular endothelial growth factor C (VEGF-C) gene transfer in rat model of secondary lymphedema
Effect of vascular endothelial growth factor C (VEGF-C) gene transfer in rat model of secondary lymphedema
复制标题
血管内皮生长因子C（VEGF-C）基因转染对大鼠继发性淋巴水肿模型的影响
DOI：
10.1016/j.vph.2008.01.010
复制
发表时间：
2008-04-01
影响因子：
4
通讯作者：
Liu, Zhiyu
中科院分区：
文献类型：
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作者：
Liu, Yanli;Fang, Yunhai;Liu, Zhiyu
继发性水肿在临床上已有很好的描述，但仍缺乏治愈方法。虽然以前有使用质粒DNA进行基因治疗的研究，但很少有人关注用于治疗水肿。因此，我们用我们的质粒pcDNA3.1-VEGF-C研究了VEGF-C基因转移治疗水肿的效果。我们制作了一个大鼠后肢继发性水肿的手术模型，并用局部皮内VEGF-C转染进行治疗，以研究基因转移的疗效。磁共振成像（MRI）（P
Secondary lymphedema has been clinically well described, but a Cure is still lacking. Although there have been previous investigations using plasmid DNA for gene therapy, few have focused on the use for the treatment of lymphedema. Therefore, we investigated the effects of VEGF-C gene transfer for the treatment of lymphedema using our plasmid pcDNA3.1-VEGF-C. We produced a surgical model of secondary lymphedema in the rat hindlimb and treated with local intradermal VEGF-C transfection to investigate the efficacy of gene transfer. Magnetic resonance imaging (MRI) (P