The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.
The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.
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DOI：
10.1007/s00005-014-0310-1
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发表时间：
2015-02
影响因子：
3.2
通讯作者：
Goraca, Anna
中科院分区：
文献类型：
--
作者：
Kowalczyk, Agata;Kleniewska, Paulina;Kolodziejczyk, Michal;Skibska, Beata;Goraca, Anna
内皮素-1 （ET-1）是一种有效的内源性血管收缩剂，主要由内皮细胞分泌。它通过两种受体起作用：ETA和ETB。除了血管收缩作用外，ET-1还会导致血管细胞纤维化并刺激活性氧的产生。ET-1诱导促炎机制，增加超氧阴离子的产生和细胞因子的分泌。最近的一项研究表明，ET-1参与NF-κB等转录因子的激活和TNF-α、IL-1、IL-6等促炎细胞因子的表达。研究还表明，在内毒素血症期间，各种动物血浆中ET-1的水平升高。一些作者指出，内皮素血浆水平与脓毒症患者的发病率/死亡率有明显的相关性。内皮素受体阻断至少可以部分消除ET-1的这些病理作用。ET-1受体拮抗剂可用于预防各种血管疾病。本文综述了目前关于内皮素受体拮抗剂和ET-1在败血症和炎症中的作用的知识。
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-κB and expression of proinflammatory cytokines including TNF-α, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases. This review summarises the current knowledge regarding endothelin receptor antagonists and the role of ET-1 in sepsis and inflammation.
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影响因子：
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作者：
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