microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines.
microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines.
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DOI：
10.1186/s41544-018-0004-7
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Rosas-Taraco, Adrian G
中科院分区：
文献类型：
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作者：
Leon-Icaza, Stephen A;Zeng, Mingtao;Rosas-Taraco, Adrian G
MicroRNAs （miRNAs）是17-24nt的单链rna。这些分子在转录后水平调控基因表达，并在病毒性急性呼吸道感染（ARIs）中差异表达，这是全球高发病率和死亡率的原因。近年来，为了发现抗病毒ARI药物靶点以及诊断、严重程度和预后的生物标志物，人们对mirna进行了研究。这篇综述分析了mirna对病毒ARIs的调控反应，包括它们在先天免疫反应中的参与，它们作为生物标志物的效用，以及它们在未来治疗和疫苗开发中的潜力。
MicroRNAs (miRNAs) are single-stranded RNAs of 17-24nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development.