Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat.
Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat.
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大鼠系膜增生性肾炎中诱导内皮素-1 和内皮素 B 型受体。
DOI：
10.1038/ki.1995.413
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发表时间：
1995
影响因子：
19.6
通讯作者：
T. Masaki
中科院分区：
文献类型：
--
作者：
A. Yoshimura;S. Iwasaki;K. Inui;T. Ideura;S. Koshikawa;M. Yanagisawa;T. Masaki
我们研究了内皮素-1（ET-1）及其受体亚型（ETAR，内皮素A型受体;和ETBR，B型受体）是否在抗胸腺细胞血清（anti-Thy-1 GN）诱导的系膜增生性肾小球肾炎大鼠模型中上调。在疾病诱导后3天和6天，肾小球RNA中的preproET-1 mRNA显著增加（分别为第0天的4.1和4.9倍），对应于系膜细胞增殖的时间，巨噬细胞浸润到肾小球的时间，以及肾小球PDGF B链mRNA表达增加的时间。免疫组化显示ET-1蛋白在肾小球系膜区和沿着肾小球毛细血管壁的内部分布，从第3天开始，第6天达到高峰。肾小球表达ET-1的细胞主要为系膜细胞、肾小球内皮细胞和单核/巨噬细胞。此外，基因和蛋白表达的ET-1与增加尿ET-1的排泄。血浆ET-1免疫反应性无增加。在抗Thy-1 GN中，ETBR mRNA的肾小球表达增加（在疾病诱导后第3天是第0天的1.5倍，第6天是第0天的3.6倍，第10天是第0天的2.7倍），但ETAR mRNA表达变化极小。这些结果表明，在抗Thy-1 GN中诱导的preproET-1 mRNA主要与ETBR mRNA表达相关。（250字处删节）
We studied whether endothelin-1 (ET-1) and its receptor subtypes (ETAR, endothelin A type receptor; and ETBR, B type receptor) were up-regulated in the glomerulus of a rat model of mesangial proliferative glomerulonephritis induced by anti-thymocyte serum (anti-Thy-1 GN). A marked increase in preproET-1 mRNA could be demonstrated in glomerular RNA 3 and six days after disease induction (4.1- and 4.9-fold vs. day 0, respectively), corresponding to the time of mesangial cell proliferation, to the time of macrophage infiltration into glomeruli, and also to the time of increase in glomerular PDGF B-chain mRNA expression. The localization of ET-1 protein in the mesangial area and along the inner aspect of the glomerular capillary wall was also demonstrated by immunohistochemistry from day 3 and maximal at day 6. The major source of the cells expressing ET-1 in glomeruli appeared to be mesangial cells, glomerular endothelial cells and monocyte/macrophages. Furthermore, both gene and protein expression of ET-1 were associated with increased urinary excretion of ET-1. There was no increase in the plasma ET-1 immunoreactivity. Glomerular expression of ETBR mRNA increased in anti-Thy-1 GN (1.5-fold vs. day 0 at day 3 after disease induction, 3.6-fold at day 6 and 2.7-fold at day 10), but there was minimal change in ETAR mRNA expression. These results suggest that preproET-1 mRNA, which is induced in anti-Thy-1 GN, is linked primarily with ETBR mRNA expression.(ABSTRACT TRUNCATED AT 250 WORDS)
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调节肾小球毛细血管内皮细胞中内皮素 1 的表达。
DOI：
10.1152/ajprenal.1991.261.1.f117
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Marsden,PA;Dorfman,DM;Collins,T;Brenner,BM;Orkin,SH;Ballermann,BJ
通讯作者：
Ballermann,BJ
内脏肾小球上皮细胞在体内可增殖并合成血小板源性生长因子B链。
DOI：
--
发表时间：
1993
期刊：
The American journal of pathology
影响因子：
--
作者：
Floege,J;Johnson,RJ;Alpers,CE;Fatemi-Nainie,S;Richardson,CA;Gordon,K;Couser,WG
通讯作者：
Couser,WG
系膜细胞中 EtA 和 EtB 受体响应环孢菌素的不同表达。
DOI：
--
发表时间：
1994
期刊：
The American journal of pathology
影响因子：
--
作者：
Takeda,M;Iwasaki,S;Hellings,SE;Yoshida,H;Homma,T;Kon,V
通讯作者：
Kon,V
内皮素在体内的肾小球作用。
DOI：
10.1172/jci114079
发表时间：
1989
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Kon,V;Yoshioka,T;Fogo,A;Ichikawa,I
通讯作者：
Ichikawa,I
影响因子：
19.6
作者：
A. Yoshimura;K. Gordon;C. Alpers;J. Floege;P. Pritzl;R. Ross;W. Couser;D. Bowen-Pope;Richard J. Johnson
通讯作者：
A. Yoshimura;K. Gordon;C. Alpers;J. Floege;P. Pritzl;R. Ross;W. Couser;D. Bowen-Pope;Richard J. Johnson