DOUBLET FREQUENCIES IN EVOLUTIONARY DISTINCT GROUPS
DOUBLET FREQUENCIES IN EVOLUTIONARY DISTINCT GROUPS
复制标题
DOI：
10.1093/nar/12.3.1749
复制
发表时间：
1984-01-01
影响因子：
14.9
通讯作者：
NUSSINOV, R
中科院分区：
文献类型：
--
作者：
NUSSINOV, R
我们分别分析了脊椎动物、非脊椎动物、DNA病毒、线粒体、RNA病毒、细菌和噬菌体序列中二核苷酸的出现频率和偏好。在这项研究中使用了来自400多个序列的50多万个核苷酸。观察到不同的模式。有些模式是所有序列共有的，有些是真核生物或原核生物共有的，而另一些则是它们内部的亚群共有的。双联体是核苷酸序列中最基本的有序成分。我们认为，它们的偏好和DNA中核苷酸的排列一般在很大程度上取决于双螺旋的构象和包装考虑。根据我们的研究结果，讨论了DNA构象的一些规律.
We analyze the dinucleotide frequencies of occurrence and preferences separately within the vertebrates, nonvertebrates, DNA viruses, mitochondria, RNA viruses, bacteria and phage sequences. Over half a million nucleotides from more than 400 sequences were used in this study. Distinct patterns are observed. Some of the patterns are common to all sequences, some to either eukaryotes or prokaryotes and others to the subgroups within them. Doublets are the most basic ingredient of order in nucleotide sequences. We suggest that their preferences and the arrangement of nucleotides in the DNA in general is determined to a large extent by the conformational and packaging considerations of the double helix. Some principles of DNA conformation are viewed in light of our results.