ANTI-VIRAL ACTIVITY OF 2 ANTIBIOTICS ISOLATED FROM A SPECIES OF STREPTOMYCES
ANTI-VIRAL ACTIVITY OF 2 ANTIBIOTICS ISOLATED FROM A SPECIES OF STREPTOMYCES
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DOI：
10.1038/206265a0
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发表时间：
1965-01-01
期刊：
影响因子：
64.8
通讯作者：
MILLS, RFN
中科院分区：
文献类型：
--
作者：
DICKINSON, L;GRIFFITHS, AJ;MILLS, RFN
抗病毒抗生素的筛选计划导致了一种未鉴定的链霉菌的发现，该链霉菌产生两种这样的物质，其分离在前一篇论文中有描述[Nature，1965，v.206，263; thisBulletin，1965，v.40，（867）]。其中之一已被确定为疏螺旋体素，所谓的16年前，因为它的活性对Borreliaspp。但当时没有观察到它对病毒的作用。疏螺旋体素在体外对几种病毒具有高度活性，这是通过单层鸡胚组织培养中病毒增殖的局部抑制来确定的，但它毒性太大，不能提供任何治疗效用的希望。第二种抗生素，名为vivomycin，延迟并经常防止接种脑心肌炎病毒的小鼠死亡，并且毒性低。没有其他病毒感染以这种方式对它作出反应，尽管它对小鼠的流感有一些影响。Vivomycin具有多糖性质，类似于细菌内毒素，并且被认为通过刺激宿主防御而起作用。P·加罗德
A screening programme for antiviral antibiotics led to the discovery of an unidentifiedStreptomyceswhich produced 2 such substances, the isolation of which is described in the preceding paper [Nature, 1965, v. 206, 263; thisBulletin, 1965, v. 40, (867)]. One of these has been identified as borrelidin, so-called 16 years ago because of its activity againstBorreliaspp. but without at that time any observations on its action on viruses. Borrelidin is highly activein vitroagainst several viruses, as determined by local inhibition of virus multiplication in mono-layer chick embryo tissue cultures, but it is too toxic to offer any hope of therapeutic utility. The second antibiotic, named vivomycin, delays and often prevents death in mice inoculated with encephalomyo-carditis virus, and has a low toxicity. No other virus infection responded to it in this way, although there was some effect on influenza in mice. Vivomycin is of polysaccharide nature, is likened to bacterial endotoxin, and is believed to act by stimulating host defences.L. P. Garrod.