Red blood cells in thrombosis
Red blood cells in thrombosis
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DOI：
10.1182/blood-2017-03-745349
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发表时间：
2017-10-19
期刊：
影响因子：
20.3
通讯作者：
Wolberg, Alisa S.
中科院分区：
文献类型：
--
作者：
Byrnes, James R.;Wolberg, Alisa S.
红细胞(RBC)历来被认为是血栓形成的被动旁观者。然而，临床和流行病学研究已发现红细胞数量和质量的异常，包括红细胞压积改变、镰状细胞病、地中海贫血、溶血性贫血和疟疾，并伴有动脉和静脉血栓形成。越来越多的机制研究表明，红细胞可以促进血栓的形成和增强血栓的稳定性。这些发现提示红细胞可能参与血栓形成的病理生理学，并揭示了以红细胞为靶点治疗以减少血栓形成的潜在策略。
Red blood cells (RBCs) have historically been considered passive bystanders in thrombosis. However, clinical and epidemiological studies have associated quantitative and qualitative abnormalities in RBCs, including altered hematocrit, sickle cell disease, thalassemia, hemolytic anemias, and malaria, with both arterial and venous thrombosis. A growing body of mechanistic studies suggests that RBCs can promote thrombus formation and enhance thrombus stability. These findings suggest that RBCs may contribute to thrombosis pathophysiology and reveal potential strategies for therapeutically targeting RBCs to reduce thrombosis.