Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis.
Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis.
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DOI：
10.1186/s40168-016-0161-6
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发表时间：
2016-04-19
期刊：
影响因子：
15.5
通讯作者：
Martin DH
中科院分区：
文献类型：
--
作者：
Zozaya M;Ferris MJ;Siren JD;Lillis R;Myers L;Nsuami MJ;Eren AM;Brown J;Taylor CM;Martin DH
细菌性阴道病（BV）的流行病学表明它是性传播的，但尚未确定传播媒介。bv相关的细菌群落很可能在性交过程中从男性转移到女性伴侣；然而，性伴侣体内的微生物群并没有得到很好的研究。利用pcr扩增的16S rDNA对一夫一妻制夫妇的阴道、男性尿道和阴茎皮肤标本进行BV相关细菌的检测。BV女性男性伴侣的阴茎皮肤和尿道微生物群与女性伴侣的阴道微生物群的相似性明显高于无伴侣的BV女性阴道微生物群。对于阴道微生物群正常的女性的男性伴侣来说，情况并非如此。女性细菌性阴道炎患者及其男性伴侣的细菌性阴道炎相关种基本一致。在女性患有细菌性阴道炎的一夫一妻制异性伴侣中，阴道微生物群与男性伴侣阴茎皮肤和尿道微生物群之间的相似性明显更高，这支持了细菌性阴道炎相关细菌分类群的性交换是常见的假设。本文的在线版本（doi:10.1186/s40168-016-0161-6）包含补充材料，可供授权用户使用。
The epidemiology of bacterial vaginosis (BV) suggests it is sexually transmissible, yet no transmissible agent has been identified. It is probable that BV-associated bacterial communities are transferred from male to female partners during intercourse; however, the microbiota of sexual partners has not been well-studied. Pyrosequencing analysis of PCR-amplified 16S rDNA was used to examine BV-associated bacteria in monogamous couples with and without BV using vaginal, male urethral, and penile skin specimens. The penile skin and urethral microbiota of male partners of women with BV was significantly more similar to the vaginal microbiota of their female partner compared to the vaginal microbiota of non-partner women with BV. This was not the case for male partners of women with normal vaginal microbiota. Specific BV-associated species were concordant in women with BV and their male partners. In monogamous heterosexual couples in which the woman has BV, the significantly higher similarity between the vaginal microbiota and the penile skin and urethral microbiota of the male partner, supports the hypothesis that sexual exchange of BV-associated bacterial taxa is common. The online version of this article (doi:10.1186/s40168-016-0161-6) contains supplementary material, which is available to authorized users.