Testicular blood flow following spinal cord injury in the Sprague Dawley rat.
Testicular blood flow following spinal cord injury in the Sprague Dawley rat.
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斯普拉格道利大鼠脊髓损伤后睾丸血流。
DOI：
10.1080/10790268.1996.11719429
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Huang,HH
中科院分区：
文献类型：
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作者：
Linsenmeyer,TA;Chang,Q;Ottenweller,J;Anesetti,R;Pogach,L;Huang,HH
脊髓损伤（SCI）后精液质量差的原因尚不清楚。一个可能的机制是睾丸血流量减少。非脊髓损伤动物的慢性睾丸缺血已被证明对精子发生有显著的不利影响。本研究旨在评估Sprague Dawley大鼠脊髓损伤后睾丸血流量。在脊髓损伤前3天、后3天和14天分别测定11只胸椎第9节段大鼠和6只假对照大鼠的睾丸血流量。用多普勒血流探头测量睾丸血流速度。采用t检验比较各组间血流量。假手术大鼠术后3天或14天血流无明显变化。然而，脊髓损伤后3天，脊髓损伤大鼠的血流量减少到脊髓损伤前的78±5% （t =-4.65, p <0.001）。在脊髓损伤后第14天，血流量仍下降到77+ 8%，（t =-3.40, p<0.05）。本研究证实脊髓损伤后，Sprague Dawley大鼠睾丸血流量减少。（J脊髓/星期三；19:183-185）
The causes of poor semen quality following spinal cord injury (SCI) are unknown. One possible mechanism is decreased testicular blood flow. Chronic testicular ischemia in non-SCI animals has been shown to have significant adverse impact on spermatogenesis. This study was designed to evaluate testicular blood flow following SCI in the Sprague Dawley rat. Testicular blood flows were determined in 11 rats with SCI at thoracic level nine (T9) and six sham control rats three days prior and three days and 14 days after SCI. Testicular blood flow velocity was measured with a Doppler flow probe. Blood flows were compared between groups using T-tests. There were no significant changes in blood flow in the sham operated rats three or 14 days after surgery. However, three days after SCI, blood flow had decreased in the SCI rats to 78 ±5 percent of the pre-SCI flow (t =-4.65 with 10 df, p <0.001). At 14 days after SCI, blood flow was still decreased to 77+8 percent, (t =-3.40 with 3 df, p<0.05). This study established that following SCI, testicular blood flow decreases in the Sprague Dawley rat.(J Spinal Cord/Wed; 19:183–185)