Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women
Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women
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DOI：
10.1016/j.ajog.2011.05.017
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发表时间：
2011-10-01
影响因子：
9.8
通讯作者：
Knapp, Robert C.
中科院分区：
文献类型：
--
作者：
Holcomb, Kevin;Vucetic, Zivjena;Knapp, Robert C.
目的：我们试图评估人附睾蛋白4 （HE4）和CA-125在绝经前妇女中区分良性、交界性和恶性盆腔肿块的能力。研究设计：我们对一项前瞻性临床试验的数据进行了亚组分析，该试验招募了接受附件肿块手术的女性。测定CA-125和HE4在绝经前妇女上皮性卵巢癌（EOC）检测中的诊断价值。结果：229例绝经前患者中，良性肿块195例（85%），EOC 18例（8%），交界性卵巢肿瘤16例（7%）。CA-125和HE4检测EOC的灵敏度分别为83.3%和88.9%。CA-125和HE4特异性分别为59.5%和91.8%。正常的HE4水平在98%的CA-125升高的女性中排除了浸润性癌症。结论：与CA-125相比，HE4在鉴别绝经前妇女附件肿块良恶性方面具有更高的特异性。
OBJECTIVE: We sought to assess the ability of human epididymis protein 4 (HE4) and CA-125 to distinguish among benign, borderline, and malignant pelvic masses in premenopausal women.STUDY DESIGN: We conducted a subset analysis of data from a prospective clinical trial that enrolled women undergoing surgery for an adnexal mass. Diagnostic performance of CA-125 and HE4 for epithelial ovarian cancer (EOC) detection in premenopausal women was determined.RESULTS: Of 229 premenopausal patients, 195 (85%) had benign masses, 18 (8%) had EOC, and 16 (7%) had borderline ovarian tumor. The sensitivity of CA-125 and HE4 for EOC detection was 83.3% and 88.9%, respectively. The specificity of CA-125 and HE4 was 59.5% and 91.8%, respectively. A normal HE4 level ruled out invasive cancer in 98% of women with an elevated CA-125.CONCLUSION: HE4 offers superior specificity compared to CA-125 for the differentiation of benign and malignant adnexal masses in premenopausal women.