ACTIVATION OF PREFRONTAL CORTEX IN CHILDREN DURING A NONSPATIAL WORKING-MEMORY TASK WITH FUNCTIONAL MRI
ACTIVATION OF PREFRONTAL CORTEX IN CHILDREN DURING A NONSPATIAL WORKING-MEMORY TASK WITH FUNCTIONAL MRI
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DOI：
10.1006/nimg.1995.1029
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发表时间：
1995-09-01
期刊：
影响因子：
5.7
通讯作者：
RAPOPORT, JL
中科院分区：
文献类型：
--
作者：
CASEY, BJ;COHEN, JD;RAPOPORT, JL
采用功能磁共振成像（fMRI）技术，研究了青春期前儿童在非空间工作记忆任务中前额叶皮层的活动模式。孩子们观察字母的序列，每当一个字母重复时，只要有一个不相同的字母插入，他们就会做出反应。在一项比较任务中，受试者监测类似的字母序列，以确定是否出现一个预先指定的目标字母。激活的位置非常接近最近的功能磁共振成像研究中观察到的成年人使用完全相同的任务。激活额下回和额中回可靠地观察到在个别科目的工作记忆任务相对于比较任务的性能。激活增加和减少的时间过程是高度一致的任务操作和相关的行为表现。据我们所知，这项研究是第一个证明功能磁共振成像的适用性，一个规范的发展人口。年龄依赖的fMRI的血流动力学反应的问题进行了讨论。(C)出版社：Academic Press
Functional magnetic resonance imaging (fMRI) was used to examine the pattern of activity of prefrontal cortex in prepubertal children during performance of a nonspatial working memory task. The children observed sequences of letters and responded whenever a letter repeated with exactly one nonidentical letter intervening. In a comparison task, subjects monitored similar sequences of letters for any occurrence of a single, prespecified target letter. Location of activation closely approximated that observed in a recent fMRI study with adults using exactly the same task. Activation of the inferior and middle frontal gyri was reliably observed within individual subjects during performance of the working memory task relative to the comparison task. Activation increased and decreased with a time course that was highly consistent with the task manipulations and correlated with behavioral performance. To our knowledge, this study is one of the first to demonstrate the applicability of fMRI to a normative developmental population. Issues of age dependence of the hemodynamic responses of fMRI are discussed. (C) 1995 Academic Press, Inc.